BDNF makes cultured dentate granule cells more resistant to hypoglycemic damage

Research output: Contribution to journalArticle

Abstract

THE aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Hypoglycaemia, Dentate gyrus, Neurotrophins, Neuronal protection, Brain insults
Original languageEnglish
Pages (from-to)1241-1244
JournalNeuroReport
Volume5
Issue number10
StatePublished - 1994
Peer-reviewedYes

Bibliographic note

Author Othberg was 1991-1996 an employee at Restorative Neurology Unit research group led by Lindvall.