Central retinal vein occlusion: Cetrain risk factors, electroretinography and an experimental treatment model.

Research output: ThesisDoctoral Thesis (compilation)

Abstract

The presence of activated protein C resistance, plasma hyperhomocysteinemia and the MTHFR C677T mutation in patients with central retinal vein occlusion were investigated and compared to a control group. Activated protein C resistance was overrepresented in the group of patients less than 50 years of age whereas this was not the case in patients more than 50 years of age. Neither hyperhomocysteinemia nor the MTHFR C677T mutation were more frequently seen in the patients independent of their age compared to the controls. Electroretinography was performed early in the course of central retinal vein occlusion, and was shown to have a good predictability concerning the development of rubeosis. We have also shown that full-field ERG, and especially the b-wave implicit time in the 30 Hz flicker ERG is a better predictor for prognosis than fluorescein angiography in patients with recent central retinal vein occlusion. An experimental model of retinal vein occlusion in the rabbit was developed to investigate if it was possible to lower the dose of streptokinase and retain a good thrombolytic effect by adding pulsed ultrasound. These results show that it is possible to halve the dose of streptokinase and still retain a good thrombolytic effect by adding pulsed ultrasound.

Details

Authors
  • Jörgen Larsson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Ophthalmology

Keywords

  • flicker, ERG, electroretinography, fluorescein angiography, rubeosis, CRVO, central retianl vein occlusion, ultrasound, streptokinase, experimental, Ophtalmology, Oftalmologi
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
  • [unknown], [unknown], Supervisor, External person
Award date1998 Oct 23
Publisher
  • Department of Ophthalmology, Lund University
Print ISBNs91-628-3072-4
StatePublished - 1998
Publication categoryResearch

Bibliographic note

Defence details Date: 1998-10-23 Time: 10:15 Place: Kvinnoklinikens föreläsningssal, Lund External reviewer(s) Name: Laatikainen, Leila Title: [unknown] Affiliation: [unknown] ---