Chemical characterization of cyanogen bromide fragments from the beta-chain of human complement factor C3

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The isolated beta-chain of human complement factor C3 (C3 beta) was fragmented by cyanogen bromide. Nine fragments were defined by gel filtration and high-pressure liquid chromatography, and characterized with respect to their Mr, amino acid composition and N-terminal amino acid sequence. Approx. 30% of the primary structure of C3 beta was determined. Alignment of the 3 N-terminal fragments allowed determination of 61 of the amino terminal residues of C3 beta. This region demonstrated 40% homology with the sequence in the N-terminal segment of the alpha-chain of the cobra venom factor.


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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medicinal Chemistry


  • *Cyanogen Bromide, Complement C3/*analysis, High Pressure Liquid, Gel, Chromatography, Amino Acid Sequence, Amino Acids/analysis, Humans, Peptide Fragments/*analysis, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)57-62
JournalFEBS Lett
Issue number1
StatePublished - 1984
Externally publishedYes

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