Closed-loop Prevention of Hypotension in the Heartbeating Brain-dead Porcine Model

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model.

Methods:
Dynamic modeling and system identification were based on in-vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. Results: The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.

Conclusion: Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances.

Significance:
Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Control Engineering
  • Anesthesiology and Intensive Care
  • Other Medical Engineering

Keywords

  • Drug delivery, Medical control systems
Original languageEnglish
Pages (from-to)1310-1317
JournalIEEE Transactions on Biomedical Engineering
Volume64
Issue number6
StatePublished - 2017 Jun
Peer-reviewedYes

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