För tidigt att rekommendera allmän screening för kolorektal cancer

Research output: Contribution to journalArticle

Abstract

Randomised controlled trials have shown that screening may significantly reduce mortality in coloretcal cancer. In the present evaluation it is shown that the reported reduction of 15 per cent, or higher, is given in relative figures. With absolute figures the reduction is only 0.15 per cent or lower. The number of individuals needed to invite for screening (NNT) biannually for 10 years to prevent one death in colorectal cancer is 1,173 (confidence interval 741-2,807). Side-effects, costs and ethical issues are seldom, or never, discussed. Postopeative follow-up may be regardes as the screening of a high-risk group. The reduced mortality seen in the metaanalysis of randomised controlled trials is here regarded as small and should also be weighed against the drawbacks of follow-up before any recommendation for more active surveillance is given.

Details

Authors
  • Göran Ekelund
  • Lars Janzon
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Clinical Medicine
Original languageEnglish
Pages (from-to)2922-2926
JournalLäkartidningen
Volume100
Issue number38
StatePublished - 2003
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)