Haemophilus influenzae and the complement system.

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Haemophilus influenzae and the complement system. / Hallström, Teresia; Riesbeck, Kristian.

In: Trends in Microbiology, Vol. Mar 4, 2010, p. 258-265.

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TY - JOUR

T1 - Haemophilus influenzae and the complement system.

AU - Hallström,Teresia

AU - Riesbeck,Kristian

PY - 2010

Y1 - 2010

N2 - The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for understanding pathogenesis and for developing vaccines and new therapies aimed at patients with, for example, chronic obstructive pulmonary disease. Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system.

AB - The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for understanding pathogenesis and for developing vaccines and new therapies aimed at patients with, for example, chronic obstructive pulmonary disease. Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system.

U2 - 10.1016/j.tim.2010.03.007

DO - 10.1016/j.tim.2010.03.007

M3 - Article

VL - Mar 4

SP - 258

EP - 265

JO - Trends in Microbiology

T2 - Trends in Microbiology

JF - Trends in Microbiology

SN - 1878-4380

ER -