Highly increased familial risks for specific lymphoma subtypes

Research output: Contribution to journalArticle

Abstract

P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

Details

Authors
  • Lynn R. Goldin
  • Magnus Bjorkholm
  • Sigurdur Y. Kristinsson
  • Ingemar Turesson
  • Ola Landgren
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • non-Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular, familial risk, lymphoma, Hodgkin lymphoma
Original languageEnglish
Pages (from-to)91-94
JournalBritish Journal of Haematology
Volume146
Issue number1
StatePublished - 2009
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)