Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse

Research output: Contribution to journalArticle

Abstract

Background: Relapse of disease is frequent in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). It is unclear whether persistent ANCA when starting maintenance therapy increases the risk of relapse. We examined the association between ANCA status and relapse in two randomised controlled trials. Methods: ANCA-positive patients in two trials, CYCLOPS and IMPROVE, were switched from cyclophosphamide to maintenance therapy after achieving clinical remission. We classified patients as being either ANCA-positive or ANCA-negative at the time they started maintenance therapy. We compared the risk of relapse in ANCA-positive and ANCA-negative patients. Results: Of 252 patients included, 102 (40%) experienced at least one relapse during the follow-up period. At the time of the switch from induction to maintenance therapy, 111 were ANCA-positive, of whom 55 (50%) relapsed, compared to 141 patients who were ANCA-negative, of whom 47 (33%) relapsed. In multivariable time-to-event analysis, a reduced risk of relapse was associated with having become ANCA-negative at the time of switching to maintenance therapy (hazard ratio 0.63, 95% confidence interval 0.42-0.95; p=0.026). In addition, initial proteinase 3 (PR3)-ANCA, younger age, lower serum creatinine, pulsed cyclophosphamide for remission induction, and mycophenolate mofetil for remission maintenance were all associated with an increased risk of relapse. Conclusions: Becoming ANCA-negative before the switch to maintenance is associated with a reduced risk of relapse. Trial registration: CYCLOPS: ClinicalTrials.gov, NCT00430105. Registered retrospectively on 31 January 2007. IMPROVE: ClinicalTrials.gov, NCT00307645. Registered retrospectively on 27 March 2006.

Details

Authors
  • Matthew David Morgan
  • Matthew Szeto
  • Michael Walsh
  • David Jayne
  • Kerstin Westman
  • Niels Rasmussen
  • Thomas F Hiemstra
  • Oliver Flossmann
  • Annelies Berden
  • Peter Höglund
  • Lorraine Harper
  • European Vasculitis Society
Organisations
External organisations
  • University of Birmingham
  • New Queen Elizabeth Hospital
  • McMaster University
  • University of Cambridge
  • Skåne University Hospital
  • Statens Serum Institute, Copenhagen
  • Royal Berkshire Hospital
  • Leiden University Medical Centre
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Clinical Medicine

Keywords

  • ANCA, ANCA-associated vasculitis, Clinical trial, Prognostic factors, Relapse, Treatment, Vasculitis
Original languageEnglish
Article number129
JournalArthritis Research and Therapy
Volume19
Issue number1
StatePublished - 2017 Jun 7
Peer-reviewedYes