Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.

Research output: Contribution to journalArticle

Abstract

The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.

Details

Authors
  • Svante Vikingsson
  • David Andersson
  • Sven Almer
  • Curt Peterson
  • Ulf Hindorf
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Gastroenterology and Hepatology
Original languageEnglish
Pages (from-to)1702-1709
JournalJournal of Crohn's & Colitis
Volume8
Issue number12
StatePublished - 2014
Peer-reviewedYes