Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.
Research output: Contribution to journal › Article
The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Journal of Crohn's & Colitis|
|State||Published - 2014|