Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998

Research output: Contribution to journalReview article

Abstract

The mechanisms underlying secondary or delayed cell death following traumatic brain injury are poorly understood. Recent evidence from experimental models suggests that widespread neuronal loss is progressive and continues in selectively vulnerable brain regions for months to years after the initial insult. The mechanisms underlying delayed cell death are believed to result, in part, from the release or activation of endogenous 'autodestructive' pathways induced by the traumatic injury. The development of sophisticated neurochemical, histopathological and molecular techniques to study animal models of TBI have enabled researchers to begin to explore the cellular and genomic pathways that mediate cell damage and death. This new knowledge has stimulated the development of novel therapeutic agents designed to modify gene expression, synthesis, release, receptor or functional activity of these pathological factors with subsequent attenuation of cellular damage and improvement in behavioral function. This article represents a compendium of recent studies suggesting that modification of post-traumatic neurochemical and cellular events with targeted pharmacotherapy can promote functional recovery following traumatic injury to the central nervous system.

Details

Authors
Organisations
External organisations
  • University of Pennsylvania
  • Copenhagen University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Pharmacotherapy, Traumatic brain injury
Original languageEnglish
Pages (from-to)731-769
Number of pages39
JournalJournal of Neurotrauma
Volume15
Issue number10
StatePublished - 1998 Oct
Peer-reviewedYes