Spermidine/spermine-N1-acetyltransferase activity in isoprenaline-stimulated rat salivary glands

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Abstract

In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of isoprenaline at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activities of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase were determined. Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine. The most striking effect was observed in parotid glands. Here, the beta-adrenergic agonist increased the activity of spermidine/spermine-N1-acetyltransferase markedly, but only slightly (if at all) that of ornithine decarboxylase. It also increased the concentrations of N1-acetylspermidine and putrescine markedly. The result obtained in this gland indicates interconversion of higher polyamines to putrescine.

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Keywords

  • Acetyltransferases, Animals, Infusions, Intravenous, Isoproterenol, Male, Organ Size, Ornithine Decarboxylase, Putrescine, Rats, Rats, Inbred Strains, Salivary Glands, Spermidine, Spermine
Original languageEnglish
Pages (from-to)249-54
Number of pages6
JournalActa Physiologica Scandinavica
Volume135
Issue number3
StatePublished - 1989 Mar
Publication categoryResearch
Peer-reviewedYes