Synthesis and characterization of FeIII(μ-OH)ZnII complexes: Effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA

Research output: Contribution to journalArticle

Abstract

The synthesis and characterization of three ligands and their respective heterobinuclear FeIIIZnII complexes were carried out, with the goal of mimicking the active site of purple acid phosphatases (PAPs). The ligand 2-hydroxy-3-(((2-hydroxy-5-methyl-3-(((2-(pyridin-2-yl)ethyl)(pyridin-2-ylmethyl)amino)methyl)benzyl)(pyridin-2ylmethyl)amino)methyl)-5-methylbenzaldehyde (H2L2) was synthesized and its complex (FeIIIZnIIL2) was used as a basis for comparison with similar complexes previously published in the literature. Subsequent modifications were conducted in the aldehyde group, where 1,2-ethanediamine and 1,4-diaminobutane were used as side chain derivatives. The compounds FeIIIZnIIL2 (1), FeIIIZnIIL2-et (2) and FeIIIZnIIL2-but (3) were characterized by spectroscopic methods (infrared and UV-Vis) and ESI-MS spectrometry. Theoretical calculations were performed to provide insights into the complex structures with FeIIIZnII structures. The hydrolytic activity was analyzed both with the model substrate 2,4-BDNPP and with DNA catalyzed by complexes 1, 2 and 3.

Details

Authors
  • Graciela Aparecida Dos Santos Silva
  • André Luiz Amorim
  • Bernardo De Souza
  • Philipe Gabriel
  • Hernán Terenzi
  • Ebbe Nordlander
  • Ademir Neves
  • Rosely A. Peralta
Organisations
External organisations
  • Federal University of Santa Catarina
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Inorganic Chemistry
Original languageEnglish
Pages (from-to)11380-11394
Number of pages15
JournalDalton Transactions
Volume46
Issue number34
StatePublished - 2017
Peer-reviewedYes