Targeting Neuroinflammation to Treat Alzheimer’s Disease

Research output: Contribution to journalReview article

Abstract

Over the past few decades, research on Alzheimer’s disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibrils. Recently, a third disease component, the neuroinflammatory reaction mediated by cerebral innate immune cells, has entered the spotlight, prompted by findings from genetic, pre-clinical, and clinical studies. Various proteins that arise during neurodegeneration, including beta-amyloid, tau, heat shock proteins, and chromogranin, among others, act as danger-associated molecular patterns, that—upon engagement of pattern recognition receptors—induce inflammatory signaling pathways and ultimately lead to the production and release of immune mediators. These may have beneficial effects but ultimately compromise neuronal function and cause cell death. The current review, assembled by participants of the Chiclana Summer School on Neuroinflammation 2016, provides an overview of our current understanding of AD-related immune processes. We describe the principal cellular and molecular players in inflammation as they pertain to AD, examine modifying factors, and discuss potential future therapeutic targets.

Details

Authors
  • A. Ardura-Fabregat
  • E. W.G.M. Boddeke
  • S. Brioschi
  • S. Castro-Gomez
  • K. Ceyzériat
  • C. Dansokho
  • T. Dierkes
  • G. Gelders
  • Michael T. Heneka
  • L. Hoeijmakers
  • A. Hoffmann
  • L. Iaccarino
  • S. Jahnert
  • K. Kuhbandner
  • G. Landreth
  • N. Lonnemann
  • P. A. Löschmann
  • R. M. McManus
  • A. Paulus
  • K. Reemst
  • J. M. Sanchez-Caro
  • A. Tiberi
  • A. van der Perren
  • A. Vautheny
  • C. Venegas
  • A. Webers
  • P. Weydt
  • T. S. Wijasa
  • X. Xiang
  • Y. Yang
Organisations
External organisations
  • Albert-Ludwigs University Freiburg
  • University Medical Center Groningen
  • Universitätsklinikum Bonn
  • DIF
  • University of Paris-Sud
  • German Center for Neurodegenerative Diseases
  • Catholic University of Leuven
  • University of Amsterdam
  • University Hospital Erlangen
  • Vita-Salute San Raffaele University
  • Fondazione San Raffaele del Monte Tabor
  • Indiana University
  • Technical University of Braunschweig
  • Pfizer
  • Scuola Normale Superiore di Pisa
  • World Orthopaedic Concern
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)1-26
Number of pages26
JournalCNS Drugs
Volume31
Issue number12
StatePublished - 2017 Dec 19
Peer-reviewedYes