The gut microbiota: A predisposing factor in obesity, diabetes and atherosclerosis

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Abstract

The cluster of pathologies comprising the metabolic syndrome (MetS) includes increased waist circumference, hyperglycemia, elevated blood pressure and hyperlipidemia. With time, these conditions present a major risk of developing obesity, type 2 diabetes and atherosclerosis. Fecal microbiota transplant (FMT) experiments performed in mice have given an intriguing foundation for a microbial-based therapy of obesity in humans. In the years 2004 - 2009, Gordon and colleagues presented ground-breaking studies on the role of the gut microbiota in host energy metabolism and proposed the hypothesis that obesity alters the composition of bacteria in the gut. Lipopolysaccharides (LPS) is a component of Gramnegative bacteria cell walls and is pro-inflammatory through activation of Toll-like receptor 4 (TLR4) on antigen-presenting cells located both in the gut and in other tissues in the body. Diabetes mellitus (DM) presents in two major forms: type I and type II, characterized by vastly different molecular events leading up to malfunction of glucose homeostasis.

Details

Authors
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area

Keywords

  • Atherosclerosis, Diabetes mellitus, Fecal microbiota transplant, Glucose homeostasis, Gut microbiota, Lipopolysaccharides, Metabolic syndrome, Microbial-based therapy, Obesity, Toll-like receptor 4
Original languageEnglish
Title of host publicationThe Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology
PublisherInterscience Wiley
Pages351-359
Number of pages9
ISBN (Electronic)9781118982907
ISBN (Print)9781118982877
StatePublished - 2016 Sep 22
Peer-reviewedYes

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