The molecular clutch model for mechanotransduction evolves

Research output: Contribution to journalReview article

Abstract

Many biological processes are influenced by the mechanical rigidity of surrounding tissues. Now, a combination of experiments and mathematical modelling has been used to describe the precise molecular and physical mechanism by which cells sense and respond to the mechanical properties of their extracellular environment through integrin-based adhesions.

Details

Authors
External organisations
  • National Heart Lung and Blood Institute
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • Integrins, Mechanotransduction, Cellular
Original languageEnglish
Pages (from-to)459-61
Number of pages3
JournalNature Cell Biology
Volume18
Issue number5
StatePublished - 2016 Apr 27
Publication categoryResearch
Peer-reviewedNo
Externally publishedYes