Towards the modelling of ageing and atherosclerosis effects in ApoE(-/-) mice aortic tissue.

Research output: Contribution to journalArticle

Abstract

The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure-stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE(-/-) and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE(-/-) mice aortas exhibit a saturation-type increase with respect to age.

Details

Authors
  • Tobias Waffenschmidt
  • Myriam Cilla
  • Pablo Sáez
  • Marta M Pérez
  • Miguel A Martínez
  • Andreas Menzel
  • Estefanía Peña
Organisations
External organisations
  • Technical University of Dortmund
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Other Medical Biotechnology
Original languageEnglish
JournalJournal of Biomechanics
Early online date2016 Feb 12
StatePublished - 2016
Peer-reviewedYes