Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway

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Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway. / Hien Tran, Thi; Ha, Do Thi; Truong, Do Minh; Duc, Loi Vu; Dao, Trong Tuan; Binh, Bui Thi; Hai, Nguyen Thanh.

In: Biomedical and Pharmacology Journal, Vol. 9, No. 2, 2016, p. 519-524.

Research output: Contribution to journalArticle

Harvard

Hien Tran, T, Ha, DT, Truong, DM, Duc, LV, Dao, TT, Binh, BT & Hai, NT 2016, 'Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway' Biomedical and Pharmacology Journal, vol. 9, no. 2, pp. 519-524. DOI: 10.13005/bpj/967

APA

Hien Tran, T., Ha, D. T., Truong, D. M., Duc, L. V., Dao, T. T., Binh, B. T., & Hai, N. T. (2016). Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway. Biomedical and Pharmacology Journal, 9(2), 519-524. DOI: 10.13005/bpj/967

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MLA

Vancouver

Author

Hien Tran, Thi ; Ha, Do Thi ; Truong, Do Minh ; Duc, Loi Vu ; Dao, Trong Tuan ; Binh, Bui Thi ; Hai, Nguyen Thanh. / Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway. In: Biomedical and Pharmacology Journal. 2016 ; Vol. 9, No. 2. pp. 519-524

RIS

TY - JOUR

T1 - Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway

AU - Hien Tran,Thi

AU - Ha,Do Thi

AU - Truong,Do Minh

AU - Duc,Loi Vu

AU - Dao,Trong Tuan

AU - Binh,Bui Thi

AU - Hai,Nguyen Thanh

PY - 2016

Y1 - 2016

N2 - p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.

AB - p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.

KW - Apoptosis

KW - Coix lacryma-jobi

KW - DNA synthesis

KW - MCF-7 cells

KW - Triolein

UR - http://www.scopus.com/inward/record.url?scp=85009403504&partnerID=8YFLogxK

U2 - 10.13005/bpj/967

DO - 10.13005/bpj/967

M3 - Article

VL - 9

SP - 519

EP - 524

JO - Biomedical and Pharmacology Journal

T2 - Biomedical and Pharmacology Journal

JF - Biomedical and Pharmacology Journal

SN - 0974-6242

IS - 2

ER -