Heiko HerwaldProfessor, Medicinsk Mikrobiell Patogenes

Forskningsområden

Ämnesklassifikation (UKÄ)

  • Medicin och hälsovetenskap
  • Mikrobiologi inom det medicinska området
  • Immunologi inom det medicinska området

Forskning

Modulation of inflammatory responses to bacterial infections

Severe infectious diseases, including sepsis, remain a serious medical challenge worldwide. Clinical symptoms of patients suffering from sepsis are a culmination of complex interactions between the infecting microorganism and host immune responses, such as the induction of overwhelming inflammatory reactions, systemic activation of the coagulation system, and impaired fibrinolysis. These alarming findings prompted many research groups, including my own, to search for novel strategies to treat severe infectious diseases. Many of these approaches are focused on so-called “host effector systems”, since evidence has accumulated that complications from an infection are caused by an over-stimulation of host defense systems that are modulated by bacteria or bacterial products. In severe infections, such as sepsis and septic shock, vascular leakage, increased cytokine levels, and coagulation/fibrinolysis dysfunction are often observed.

My research projects aim to identify and characterize molecular mechanisms that lead to these complications. To accomplish these tasks various in vitroex vivo, and in vivo models will be employed. The results obtained from our investigations have a chance to open new routes for development of diagnostic tools and the discovery of novel treatments in severe infectious diseases.

Senaste forskningsoutput

Yongzhi Wang, Luo, L., Oscar Braun, Westman, J., Raed Madhi, Heiko Herwald, Mörgelin, M. & Henrik Thorlacius 2018 dec 1 I : Scientific Reports. 8, 1, 4020

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Macrae, F. L., Duval, C., Praveen Papareddy, Baker, S. R., Yuldasheva, N., Kearney, K. J., McPherson, H. R., Asquith, N., Konings, J., Casini, A., Degen, J. L., Connell, S. D., Philippou, H., Wolberg, A. S., Heiko Herwald & Ariëns, R. A. S. 2018 aug 1 I : Journal of Clinical Investigation. 128, 8, s. 3356-3368 13 s.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Halldorsdottir, H. D., Eriksson, J., Persson, B. P., H. Herwald, Lindbom, L., Weitzberg, E. & Oldner, A. 2018 mar 22 I : Acta Anaesthesiologica Scandinavica.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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