Absence of Parallel Fibre to Purkinje Cell LTD During Eyeblink Conditioning

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Long-term depression (LTD) of parallel fibre/Purkinje cell synapses has been the favoured explanation for cerebellar motor learning such as classical eyeblink conditioning. Previous evidence against this interpretation has been contested. Here we wanted to test whether a classical conditioning protocol causes LTD. We applied a conditioning protocol, using a train of electrical pulses to the parallel fibres as the conditional stimulus. In order to rule out indirect effects caused by antidromic granule cell activation or output from Purkinje cells that might produce changes in Purkinje cell responsiveness, we focused the analysis on the first pulse in the conditional stimulus, that is, before any indirect effects would have time to occur. Purkinje cells learned to respond with a firing pause to the conditional stimulus. Yet, there was no depression of parallel fibre excitation after training.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Pompeu Fabra University
  • Linnaeus University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cellbiologi
  • Neurovetenskaper
  • Cell- och molekylärbiologi
Originalspråkengelska
Artikelnummer14777
TidskriftScientific Reports
Volym8
Utgivningsnummer1
StatusPublished - 2018 dec 1
PublikationskategoriForskning
Peer review utfördJa