Associations of Maternal Diabetes During Pregnancy with Overweight in Offspring: Results from the Prospective TEDDY Study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Objective: This study aimed to determine the relationship between different forms of, and potential pathways between, maternal diabetes and childhood obesity at different ages. Methods: Prospective cohort data from The Environmental Determinants of Diabetes in the Young (TEDDY) study, which was composed of 5,324 children examined from 0.25 to 6 years of age, were analyzed. Cross-sectional and longitudinal analyses taking into account potential confounders and effect modifiers such as maternal prepregnancy BMI and birth weight z scores were performed. Results: Offspring of mothers with gestational diabetes mellitus (GDM) or type 1 diabetes mellitus (T1DM) showed a higher BMI standard deviation score and increased risk for overweight and obesity at 5.5 years of age than offspring of mothers without diabetes. While these associations could be substantially explained by maternal prepregnancy BMI in offspring of mothers with GDM, significant associations disappeared after adjustment for birth weight z scores in offspring of T1DM mothers. Furthermore, overweight risk became stronger with increasing age in offspring of mothers with diabetes compared with offspring of mothers without diabetes. Conclusions: Maternal diabetes is associated with increased risk of offspring overweight, and the association appears to get stronger as children grow older. Indeed, intrauterine exposure to maternal T1DM may predispose children to later obesity through increased birth weight, while maternal BMI is more important in children exposed to GDM.

Detaljer

Författare
  • TEDDY Study Group
  • Anitha Pitchika
  • Kendra Vehik
  • Sandra Hummel
  • Jill M. Norris
  • Ulla M. Uusitalo
  • Jimin Yang
  • Suvi M. Virtanen
  • Sibylle Koletzko
  • Carin Andrén Aronsson
  • Anette G. Ziegler
  • Andreas Beyerlein
Enheter & grupper
Externa organisationer
  • Klinikum rechts der Isar
  • University of South Florida
  • National Institute for Health and Welfare
  • University of Tampere
  • Pirkanmaa Hospital District
  • Technical University of Munich
  • University of Colorado
  • Helmholtz Zentrum München
  • Tampere University Hospital
  • Dr. von Haunersches Kinderspital
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes
Originalspråkengelska
Sidor (från-till)1457-1466
Antal sidor10
TidskriftObesity
Volym26
Utgivningsnummer9
StatusPublished - 2018
PublikationskategoriForskning
Peer review utfördJa