Modulation of Calcium Overload and Calpain Activity

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Tübingen
  • University of Modena
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Oftalmologi
Originalspråkengelska
Sidor (från-till)48-60
Antal sidor13
TidskriftRSC Drug Discovery Series
Volym2019-January
Utgivningsnummer66
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa