Co-operative Radio-Immune-Stimulating Cancer Therapy
Bertil R.R.
ABSTRACT
In a clinical study at Lund University directed by Leif G. Salford at al., we found that Immunizations with a vaccine of autologous tumour-cells transduced with the genes for Interferongamma (IFN), in patients with glioblastoma multiforme is safe, feasible and prolongs survival significantly as compared to only surgery and radiotherapy.
During 1998-2001 Immunization with syngeneic IFN secreting tumour cells was studied in Fischer-344 rats with N29 glioma tumours implanted on both flanks, In these studies the combination of radiation therapy and immunization with IFN transfected tumour-cells surprisingly showed a remarkable decrease (p