Research output per year
Research output per year
- 1 - 50 out of 68 results
Search results
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2025
Tertiary lymphoid structures in high-grade serous tubo-ovarian carcinoma: anatomical site matters
Westbom-Fremer, S., Tran, L., Ebbesson, A., Martin de la Fuente, L., Jönsson, J.-M., Kannisto, P., Veerla, S. & Hedenfalk, I., 2025 Jan 3, In: Cancer Immunology Immunotherapy. 74, 56.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
A Versatile and Upgraded Version of the LundTax Classification Algorithm Applied to Independent Cohorts
Cotillas, E. A., Bernardo, C., Veerla, S., Liedberg, F., Sjödahl, G. & Eriksson, P., 2024 Dec, In: Journal of Molecular Diagnostics. 26, 12, p. 1081-1101 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer
Wang, K., Zerdes, I., Johansson, H. J., Sarhan, D., Sun, Y., Kanellis, D. C., Sifakis, E. G., Mezheyeuski, A., Liu, X., Loman, N., Hedenfalk, I., Bergh, J., Bartek, J., Hatschek, T., Lehtiö, J., Matikas, A. & Foukakis, T., 2024 Dec, In: Nature Communications. 15, 1, 3837.Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular patterns of resistance to immune checkpoint blockade in melanoma
Lauss, M., Phung, B., Borch, T. H., Harbst, K., Kaminska, K., Ebbesson, A., Hedenfalk, I., Yuan, J., Nielsen, K., Ingvar, C., Carneiro, A., Isaksson, K., Pietras, K., Svane, I. M., Donia, M. & Jönsson, G., 2024 Dec, In: Nature Communications. 15, 1, 3075.Research output: Contribution to journal › Article › peer-review
Open Access -
Tumor purity estimated from bulk DNA methylation can be used for adjusting beta values of individual samples to better reflect tumor biology
Sasiain, I., Nacer, D. F., Aine, M., Veerla, S. & Staaf, J., 2024 Dec, In: NAR Genomics and Bioinformatics. 6, 4, lqae146.Research output: Contribution to journal › Article › peer-review
Open Access -
Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance
Albrecht, J., Müller, M., Hafstað, V., Kaminska, K., Vallon-Christersson, J., Honeth, G. & Persson, H., 2024 Aug 6, (E-pub ahead of print) In: Molecular Oncology.Research output: Contribution to journal › Article › peer-review
Open Access -
Kataegis in clinical and molecular subgroups of primary breast cancer
Veerla, S. & Staaf, J., 2024 Apr 24, In: npj Breast Cancer. 10, 1, p. 1-13 32.Research output: Contribution to journal › Article › peer-review
Open Access -
Polydopamine functionalized dendritic fibrous silica nanoparticles as a generic platform for nucleic acid-based biosensing
Xue, X., Persson, H. & Ye, L., 2024 Mar 5, In: Microchimica Acta. 191, 4, 180.Research output: Contribution to journal › Article › peer-review
Open Access -
The role of extracellular vesicle fusion with target cells in triggering systemic inflammation
Papareddy, P., Tapken, I., Kroh, K., Varma Bhongir, R. K., Rahman, M., Baumgarten, M., Cim, E. I., Györffy, L., Smeds, E., Neumann, A., Veerla, S., Olinder, J., Thorlacus, H., Ryden, C., Bartakova, E., Holub, M. & Herwald, H., 2024 Feb 7, In: Nature Communications. 15, 1150.Research output: Contribution to journal › Article › peer-review
Open Access -
FOXL2 Mutation Status in Sex Cord-stromal Tumors Cannot be Predicted by Morphology
Wessman, S., Fuentes, B. B., Severin-Karlsson, J., Westbom-Fremer, S., Nistér, M., Kokaraki, G., Petta, T. B., Haglund, F. & Carlson, J. W., 2024 Jan, In: International Journal of Gynecological Pathology. 43, 1, p. 78-89 12 p.Research output: Contribution to journal › Article › peer-review
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An integrated omics approach highlights how epigenetic events can explain and predict response to neoadjuvant chemotherapy and bevacizumab in breast cancer
Fleischer, T., Haugen, M. H., Ankill, J., Silwal-Pandit, L., Børresen-Dale, A. L., Hedenfalk, I., Hatschek, T., Tost, J., Engebraaten, O. & Kristensen, V. N., 2024, In: Molecular Oncology. 18, 8, p. 2042-2059Research output: Contribution to journal › Article › peer-review
Open Access -
Genomic alterations in ovarian endometriosis and subsequently diagnosed ovarian carcinoma
Linder, A., Westbom-Fremer, S., Mateoiu, C., Olsson Widaja, A., Österlund, T., Veerla, S., Ståhlberg, A., Ulfenborg, B., Hedenfalk, I. & Sundfeldt, K., 2024, In: Human Reproduction. 39, 5, p. 1141-1154Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Improved detection of clinically relevant fusion transcripts in cancer by machine learning classification
Hafstað, V., Häkkinen, J., Larsson, M., Staaf, J., Vallon-Christersson, J. & Persson, H., 2023 Dec 18, In: BMC Genomics. 24, 1, 783.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteogenomics decodes the evolution of human ipsilateral breast cancer
De Marchi, T., Pyl, P. T., Sjöström, M., Reinsbach, S. E., DiLorenzo, S., Nystedt, B., Tran, L., Pekar, G., Wärnberg, F., Fredriksson, I., Malmström, P., Fernö, M., Malmström, L., Malmstöm, J. & Niméus, E., 2023 Dec, In: Communications Biology. 6, 1, 139.Research output: Contribution to journal › Article › peer-review
Open Access -
A deep tabular data learning model predicting cisplatin sensitivity identifies BCL2L1 dependency in cancer
Nasimian, A., Ahmed, M., Hedenfalk, I. & Kazi, J. U., 2023, In: Computational and Structural Biotechnology Journal. 21, p. 956-964 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Breast cancer associated CD169+ macrophages possess broad immunosuppressive functions but enhance antibody secretion by activated B cells
Gunnarsdottir, F. B., Briem, O., Lindgren, A. Y., Källberg, E., Andersen, C., Grenthe, R., Rosenqvist, C., Rydberg Millrud, C., Wallgren, M., Viklund, H., Bexell, D., Johansson, M. E., Hedenfalk, I., Hagerling, C. & Leandersson, K., 2023, In: Frontiers in Immunology. 14, 1180209.Research output: Contribution to journal › Article › peer-review
Open Access -
CD169+ Macrophages in Primary Breast Tumors Associate with Tertiary Lymphoid Structures, Tregs and a Worse Prognosis for Patients with Advanced Breast Cancer
Briem, O., Källberg, E., Kimbung, S., Veerla, S., Stenström, J., Hatschek, T., Hagerling, C., Hedenfalk, I. & Leandersson, K., 2023, In: Cancers. 15, 4, 1262.Research output: Contribution to journal › Article › peer-review
Open Access -
Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer: A secondary analysis of a randomized clinical trial
Stenmark Tullberg, A., Sjöström, M., Tran, L., Niméus, E., Killander, F., Kovács, A., Lundstedt, D., Holmberg, E. & Karlsson, P., 2023, In: Journal for ImmunoTherapy of Cancer. 11, 5, e006618.Research output: Contribution to journal › Article › peer-review
Open Access -
Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer: a long-term follow-up of the SweBCG91RT randomized trial
Egelberg, M., De Marchi, T., Pekar, G., Tran, L., Bendahl, P. O., Tullberg, A. S., Holmberg, E., Karlsson, P., Farnebo, M., Killander, F. & Nimeús, E., 2023, In: Molecular Oncology. 17, 10, p. 2029-2040Research output: Contribution to journal › Article › peer-review
Open Access -
Perturbation and stability of PAM50 subtyping in population-based primary invasive breast cancer
Veerla, S., Hohmann, L., Nacer, D. F., Vallon-Christersson, J. & Staaf, J., 2023, In: npj Breast Cancer. 9, 1, 83.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? A Study of Paired Core-Needle Biopsies and Surgical Specimens in Early Breast Cancer
Saghir, H., Veerla, S., Malmberg, M., Rydén, L., Ehinger, A., Saal, L. H., Vallon-Christersson, J., Borg, Å., Hegardt, C., Larsson, C., Haidar, A., Hedenfalk, I., Loman, N. & Kimbung, S., 2022 Aug 18, In: Cancers. 14, 16, p. 1-16 4000.Research output: Contribution to journal › Article › peer-review
Open Access -
RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
Staaf, J., Häkkinen, J., Hegardt, C., Saal, L. H., Kimbung, S., Hedenfalk, I., Lien, T., Sørlie, T., Naume, B., Russnes, H., Marcone, R., Ayyanan, A., Brisken, C., Malterling, R. R., Asking, B., Olofsson, H., Lindman, H., Bendahl, P.-O., Ehinger, A. & Larsson, C. & 5 others, , 2022 Aug 16, In: npj Breast Cancer. 8, p. 1-17 94.Research output: Contribution to journal › Article › peer-review
Open Access -
Interferon Alpha-Inducible Protein 27 Expression Is Linked to Disease Severity in Chronic Infection of Both HIV-1 and HIV-2
Palm, A. A., Veerla, S., Lindman, J., Isberg, P.-E., Johansson, E., Biague, A., Månsson, F., Norrgren, H., Esbjörnsson, J., Medstrand, P. & Jansson, M., 2022 Jun 1, In: Frontiers in Virology. 2Research output: Contribution to journal › Article › peer-review
Open Access -
Difficulties in diagnostics of lung tumours in biopsies: An interpathologist concordance study evaluating the international diagnostic guidelines
Ericson Lindquist, K., Ciornei, C., Westbom-Fremer, S., Gudinaviciene, I., Ehinger, A., Mylona, N., Urdar, R., Lianou, M., Svensson, F., Seidal, T., Haglund, F., Dobra, K., Béndek, M., Bardóczi, E., Szablewska, A., Witkowski, M., Ramnefjell, M., De Las Casas, L. E., Gulyas, M. & Hegedus, A. & 2 others, , 2022, In: Journal of Clinical Pathology. 75, 5, p. 302-309 jclinpath-2020-207257.Research output: Contribution to journal › Article › peer-review
Open Access -
SRIQ clustering: A fusion of Random Forest, QT clustering, and KNN concepts
Karlström, J., Aine, M., Staaf, J. & Veerla, S., 2022, In: Computational and Structural Biotechnology Journal. 20, p. 1567-1579 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
MET Expression and Cancer Stem Cell Networks Impact Outcome in High-Grade Serous Ovarian Cancer
Bååth, M., Jönsson, J.-M., Westbom Fremer, S., Martin de la Fuente, L., Tran, L., Malander, S., Kannisto, P., Måsbäck, A., Honeth, G. & Hedenfalk, I., 2021 May 14, In: Genes. 12, 5, 742.Research output: Contribution to journal › Article › peer-review
Open Access -
Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer
Matikas, A., Wang, K., Lagoudaki, E., Acs, B., Zerdes, I., Hartman, J., Azavedo, E., Bjöhle, J., Carlsson, L., Einbeigi, Z., Hedenfalk, I., Hellström, M., Lekberg, T., Loman, N., Saracco, A., von Wachenfeldt, A., Rotstein, S., Bergqvist, M., Bergh, J. & Hatschek, T. & 1 others, , 2021 Apr 1, In: ESMO Open. 6, 2, 100076.Research output: Contribution to journal › Article › peer-review
Open Access -
Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer
Kaminska, K., Akrap, N., Staaf, J., Alves, C. L., Ehinger, A., Ebbesson, A., Hedenfalk, I., Beumers, L., Veerla, S., Harbst, K., Ehmsen, S., Borgquist, S., Borg, Å., Pérez-Fidalgo, A., Ditzel, H. J., Bosch, A. & Honeth, G., 2021 Feb 18, In: Breast cancer research : BCR. 23, 1, p. 26Research output: Contribution to journal › Article › peer-review
Open Access -
A Distinctive Adnexal (Usually Paratubal) Neoplasm Often Associated with Peutz-Jeghers Syndrome and Characterized by STK11 Alterations (STK11 Adnexal Tumor): A Report of 22 Cases
Bennett, J. A., Young, R. H., Howitt, B. E., Croce, S., Wanjari, P., Zhen, C., Da Cruz Paula, A., Meserve, E., Schoolmeester, J. K., Westbom-Fremer, S., Benzi, E., Patil, N. M., Kooreman, L., El-Bahrawy, M., Zannoni, G. F., Krausz, T., McCluggage, W. G., Weigelt, B., Ritterhouse, L. L. & Oliva, E., 2021, In: American Journal of Surgical Pathology. 45, 8, p. 1061-1074 001677.Research output: Contribution to journal › Article › peer-review
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Common Susceptibility Loci for Male Breast Cancer
Maguire, S., Olsson, H., Hedenfalk, I., Orr, N. & kConFab, 2021, In: Journal of the National Cancer Institute. 113, 4, p. 453-461 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of multiple transcriptomic gene risk signatures in male breast cancer
Bayani, J., Poncet, C., Crozier, C., Neven, A., Piper, T., Cunningham, C., Sobol, M., Aebi, S., Benstead, K., Bogler, O., Dal Lago, L., Fraser, J., Hilbers, F., Hedenfalk, I., Korde, L., Linderholm, B., Martens, J., Middleton, L., Murray, M. & Kelly, C. & 17 others, , 2021, In: npj Breast Cancer. 7, 1, 98.Research output: Contribution to journal › Article › peer-review
Open Access -
Homologous recombination repair mechanisms in serous endometrial cancer
Jönsson, J. M., Bååth, M., Björnheden, I., Sahin, I. D., Måsbäck, A. & Hedenfalk, I., 2021, In: Cancers. 13, 2, 15 p., 254.Research output: Contribution to journal › Article › peer-review
Open Access -
PD-L1 Testing in Cytological Non-Small Cell Lung Cancer Specimens: A Comparison with Biopsies and Review of the Literature
Mansour, M. S. I., Lindquist, K. E., Seidal, T., Mager, U., Mohlin, R., Tran, L., Hejny, K., Holmgren, B., Violidaki, D., Dobra, K., Dejmek, A., Planck, M. & Brunnström, H., 2021, In: Acta Cytologica. 65, 6, p. 501-509Research output: Contribution to journal › Article › peer-review
Open Access -
Protein signature predicts response to neoadjuvant treatment with chemotherapy and bevacizumab in HER2-negative breast cancers
Haugen, M. H., Lingjærde, O. C., Hedenfalk, I., Garred, Ø., Borgen, E., Loman, N., Hatschek, T., Børresen-Dale, A. L., Naume, B., Mills, G. B., Mælandsmo, G. M. & Engebraaten, O., 2021, In: JCO Precision Oncology. 5, p. 286-306 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteogenomic Workflow Reveals Molecular Phenotypes Related to Breast Cancer Mammographic Appearance
De Marchi, T., Pyl, P. T., Sjöström, M., Klasson, S., Sartor, H., Tran, L., Pekar, G., Malmström, J., Malmström, L. & Niméus, E., 2021, In: Journal of Proteome Research. 20, 5, p. 2983-3001 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression
Stenström, J., Hedenfalk, I. & Hagerling, C., 2021, In: Breast Cancer Research. 23, 1, 27.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
A multiplex biomarker assay improves the diagnostic performance of HE4 and CA125 in ovarian tumor patients
Leandersson, P., Åkesson, A., Hedenfalk, I., Malander, S. & Borgfeldt, C., 2020 Oct, In: PLoS ONE. 15, 10 October, e0240418.Research output: Contribution to journal › Article › peer-review
Open Access -
SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery
Bååth, M., Westbom-Fremer, S., Martin de la Fuente, L., Ebbesson, A., Davis, J., Malander, S., Måsbäck, A., Kannisto, P. & Hedenfalk, I., 2020 Sept, In: Molecular and Cellular Oncology. 7, 6, 1805094.Research output: Contribution to journal › Article › peer-review
Open Access -
PD-1/PD-L1 expression and tumor-infiltrating lymphocytes are prognostically favorable in advanced high-grade serous ovarian carcinoma
Martin de la Fuente, L., Westbom-Fremer, S., Arildsen, N. S., Hartman, L., Malander, S., Kannisto, P., Måsbäck, A. & Hedenfalk, I., 2020 Jul, In: Virchows Archiv: an international journal of pathology. 477, 1, p. 83-91 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Simvastatin is a potential candidate drug in ovarian clear cell carcinomas
Arildsen, N. S. & Hedenfalk, I., 2020, In: Oncotarget. 11, 40, p. 3660-3674 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Crizotinib and PARP inhibitors act synergistically by triggering apoptosis in high-grade serous ovarian cancer
Sahin, I. D., Jönsson, J. M. & Hedenfalk, I., 2019 Dec 10, In: Oncotarget. 10, 65, p. 6981-6996 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Detecting TP53 mutations in diagnostic and archival liquid-based Pap samples from ovarian cancer patients using an ultra-sensitive ddPCR method
Arildsen, N. S., Martin de la Fuente, L., Måsbäck, A., Malander, S., Forslund, O., Kannisto, P. & Hedenfalk, I., 2019 Oct 29, In: Scientific Reports. 9, 1, p. 1-8 15506.Research output: Contribution to journal › Article › peer-review
Open Access -
Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration
Offer, S., Menard, J., Enriquez Perez, J., Goncalves De Oliveira, K., Indira Chandran, V., Johansson, M. C., Bång-Rudenstam, A., Siesjö, P., Ebbesson, A., Hedenfalk, I., Maly Sundgren, P., Darabi, A. & Belting, M., 2019 Jun 7, In: Journal of Experimental & Clinical Cancer Research. 38, 241.Research output: Contribution to journal › Article › peer-review
Open Access -
Afadin cooperates with Claudin-2 to promote breast cancer metastasis
Tabariès, S., McNulty, A., Ouellet, V., Annis, M. G., Dessureault, M., Vinette, M., Hachem, Y., Lavoie, B., Omeroglu, A., Simon, H. G., Walsh, L. A., Kimbung, S., Hedenfalk, I. & Siegel, P. M., 2019, In: Genes & Development. 33, 3-4, p. 180-193 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A targeted mass spectrometry strategy for developing proteomic biomarkers: a case study of epithelial ovarian cancer
Huttenhain, R., Choi, M., Martin de la Fuente, L., Oehl, K., Chang, C.-Y., Zimmermann, A.-K., Malander, S., Olsson, H., Surinova, S., Clough, T., Heinzelmann-Schwarz, V., Wild, P. J., Dinulescu, D., Niméus, E., Vitek, O. & Aebersold, R., 2019, In: Molecular and Cellular Proteomics. 18, 9, p. 1836-1850Research output: Contribution to journal › Article › peer-review
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2018
Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
Severson, T. M., Kim, Y., Joosten, S. E. P., Schuurman, K., Van Der Groep, P., Moelans, C. B., Ter Hoeve, N. D., Manson, Q. F., Martens, J. W., Van Deurzen, C. H. M., Barbe, E., Hedenfalk, I., Bult, P., Smit, V. T. H. B. M., Linn, S. C., Van Diest, P. J., Wessels, L. & Zwart, W., 2018 Dec 1, In: Nature Communications. 9, 1, 482.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of male breast cancer: Results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program
Cardoso, F., Bartlett, J. M. S., Slaets, L., van Deurzen, C. H. M., van Leeuwen-Stok, E., Porter, P., Linderholm, B., Hedenfalk, I., Schröder, C., Martens, J., Bayani, J., van Asperen, C., Murray, M., Hudis, C., Middleton, L., Vermeij, J., Punie, K., Fraser, J., Nowaczyk, M. & Rubio, I. T. & 16 others, , 2018 Feb 1, In: Annals of Oncology. 29, 2, p. 405-417Research output: Contribution to journal › Article › peer-review
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Assessment of early response biomarkers in relation to long-term survival in patients with HER2-negative breast cancer receiving neoadjuvant chemotherapy plus bevacizumab: Results from the Phase II PROMIX trial
Kimbung, S., Markholm, I., Bjöhle, J., Lekberg, T., Wachenfeldt, V. A., Azavedo, E., Saracco, A., Hellström, M., Veerla, S., Paquet, E., Bendahl, P. O., Fernö, M., Bergh, J., Loman, N., Hatschek, T. & Hedenfalk, I., 2018, In: International Journal of Cancer. 142, 3, p. 618-628Research output: Contribution to journal › Article › peer-review
Open Access -
Claudin-4 Expression is Associated with Survival in Ovarian Cancer but Not with Chemotherapy Response
Martín De La Fuente, L., Malander, S., Hartman, L., Jönsson, J. M., Ebbesson, A., Nilbert, M., Måsbäck, A. & Hedenfalk, I., 2018, In: International Journal of Gynecological Pathology. 37, 2, p. 101-109Research output: Contribution to journal › Article › peer-review
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Ghrelin expression is associated with a favorable outcome in male breast cancer
Grönberg, M., Nilsson, C., Markholm, I., Hedenfalk, I., Blomqvist, C., Holmberg, L., Tiensuu Janson, E. & Fjällskog, M. L., 2018, In: Scientific Reports. 8, 1, 13586.Research output: Contribution to journal › Article › peer-review
Open Access