The research group is addressing choice of primary surgery in breast and axilla based on risk factors for nodal metastasis (LR) and local recurrence (ENM) and the rehabilitation process (MM/LR). The risk for nodal metastasis is less than 30% but all patients undergo a staging procedure. By studying patient- and tumor related factors in large population based cohorts we aim to define a clinically useful nomogram for risk of nodal metastasis. This will ultimately result in omission of unnecessary surgical staging. Risk factors for local recurrence by proteomic- and genomic analysis are identified in well-defined cohorts including tissue from primary tumors and local relapses. These risk factors can serve as a treatment decision tool for local therapy. The need for support and rehabilitation varies between individuals after breast cancer surgery.With the aim to optimize recovery we are evaluating the effect of an intervention where psychological distress is used as an indicator for individualized rehabilitation.