Research output per year
Research output per year
Unit profile
Description
In this group we study how metastatic processes depend on suppression of the immune response and how the immune system actually instead promotes breast cancer metastasis. The research has a strong translational character with clinical collaborations and primary material as base in all projects. The focus is on immunosuppressive cell populations and metastatic processes in breast cancer. Understanding the immune suppression in breast cancer patients may lead to novel treatment modalities aimed to hinder this phenomenon which would eventually encumber the devastating progression of breast cancer metastasis.Research
Karin Leandersson is Research Group Leader for this research groupUKÄ subject classification
- Cancer and Oncology
- Immunology in the medical area
- Cell and Molecular Biology
Free keywords
- Tumor immunology
- immune supression
- breast cancer
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Dickson Adah
- Cancer Immunology, Malmö - Postdoctoral fellow
- LUCC: Lund University Cancer Centre - Postdoc
Person
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Oscar Briem
- Cancer Immunology, Malmö - Doctoral student
- LUCC: Lund University Cancer Centre - Doctoral student
Person
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Kristina Ekström-Holka
- LUCC: Lund University Cancer Centre - Research support
- Cancer Immunology, Malmö - Laboratory engineer
Person
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
Mezheyeuski, A., Backman, M., Mattsson, J., Martín-Bernabé, A., Larsson, C., Hrynchyk, I., Hammarström, K., Ström, S., Ekström, J., Mauchanski, S., Khelashvili, S., Lindberg, A., Agnarsdóttir, M., Edqvist, P. H., Huvila, J., Segersten, U., Malmström, P-U., Botling, J., Nodin, B., Hedner, C., & 10 others, 2023, In: EBioMedicine. 88, p. 1-18 104452.Research output: Contribution to journal › Article › peer-review
Open Access -
Breast cancer associated CD169+ macrophages possess broad immunosuppressive functions but enhance antibody secretion by activated B cells
Gunnarsdottir, F. B., Briem, O., Lindgren, A. Y., Källberg, E., Andersen, C., Grenthe, R., Rosenqvist, C., Rydberg Millrud, C., Wallgren, M., Viklund, H., Bexell, D., Johansson, M. E., Hedenfalk, I., Hagerling, C. & Leandersson, K., 2023, In: Frontiers in Immunology. 14, 1180209.Research output: Contribution to journal › Article › peer-review
Open Access -
CD169+ Macrophages in Primary Breast Tumors Associate with Tertiary Lymphoid Structures, Tregs and a Worse Prognosis for Patients with Advanced Breast Cancer
Briem, O., Källberg, E., Kimbung, S., Veerla, S., Stenström, J., Hatschek, T., Hagerling, C., Hedenfalk, I. & Leandersson, K., 2023, In: Cancers. 15, 4, 1262.Research output: Contribution to journal › Article › peer-review
Open Access
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Novel myeloid immune cell mechanisms in tumor progression and immune evasion
Briem, O., Leandersson, K. & Källberg, E.
2021/05/01 → 2025/05/01
Project: Dissertation
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The emerging pathogen Haemophilus influenzae – host/ cell interactions
Thofte, O., Riesbeck, K., Jalalvand, F. & Leandersson, K.
Project: Dissertation
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The leukocyte complexity and mutational landscape of periampullary adenocarcinoma: morphology matters
Lundgren, S., Jirström, K., Eberhard, J., Karnevi, E. & Leandersson, K.
2015/10/01 → 2019/12/13
Project: Dissertation
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