Understanding and therapeutic targeting of lysosome-dependent cell death 1. Deciphering the molecular machinery of lysosome-dependent cell death and its interactions with other cell death and survival processes 2. Understanding the role of lysosomes in diseases with altered cell death 3. Therapeutic modulation of lysosome-dependent cell death 4. Development of novel tools and methods for studying lysosome-dependent cell death Artificial intelligence applications in biomedical science 1. Use of artificial intelligence for biomedical image analysis 2. Use of artificial intelligence for protein function and structure prediction and modelling 3. Use of artificial intelligence for integrating biomedical "big data" such as proteomics and genomics datasets Besides our core areas we are involved in several collaborations and research networks.