Research output per year
Research output per year
Unit profile
Description
In this group we study the tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D4 (LTD4) and prostaglandins (PGE2) and their respective receptors. These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. Several of the observations and ideas are generated from our analyses of human colon cancer materials. Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment.
Subject classification (UKÄ)
- Basic Cancer Research
- Cancer and Oncology
- Immunology in the Medical Area (including Cell and Immunotherapy)
Free keywords
- Inflammation
- leukotrienes
- colon cancer
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer
Topi, G., Satapathy, S. R., Ghatak, S., Hellman, K., Ek, F., Olsson, R., Ehrnström, R., Lydrup, M. L. & Sjölander, A., 2024 Dec, In: Cell Communication and Signaling. 22, 1, 198.Research output: Contribution to journal › Article › peer-review
Open Access -
LGR5 Expression Predicting Poor Prognosis Is Negatively Correlated with WNT5A in Colon Cancer
Mehdawi, L. M., Ghatak, S., Chakraborty, P., Sjölander, A. & Andersson, T., 2023 Nov, In: Cells. 12, 22, 2658.Research output: Contribution to journal › Article › peer-review
Open Access -
DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients
Ghatak, S., Satapathy, S. R. & Sjölander, A., 2023, In: International Journal of Molecular Sciences. 24, 4, 3409.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active