In this group we study the tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D4 (LTD4) and prostaglandins (PGE2) and their respective receptors. These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. Several of the observations and ideas are generated from our analyses of human colon cancer materials. Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment.