Research output per year
Research output per year
Unit profile
Research
We have described the structure and function of human cystatin C and its gene. We have shown that the plasma level of cystatin C is the best marker for glomerular filtration rate, GFR, and that a new disorder, “Shrunken-Pore-Syndrome”, with a high prevalence and a very high mortality, can be identified my measuring cystatin C. We are studying the pathophysiology of the disorder and how to treat it. We have determined the mechanism by which a mutation in the cystatin C gene causes an amyloid deposition of the protein in brain arteries producing brain hemorrhage in young adults. The mechanism is similar to that occurring in other common amyloid disorders, e.g, Alzhemier´s and Parkinson´s disease. We develop substances interfering in this mechanism. We have produced new antibacterial and antiviral substances, based upon the structure of cystatin C, and continue to improve them. Some of the substances are active against bacterial strains resistent towards all presently available antibiotics.
UKÄ subject classification
- Clinical Laboratory Medicine
- Medicinal Chemistry
- Urology and Nephrology
Free keywords
- Amyloidosis
- antibiotics
- cerebral haemorrhage
- creatinine
- cystatin C
- cystatins
- eGFR
- estimated GFR
- GFR
- glomerular filtration rate
- kidney
- renal
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Anders Grubb
- Cystatin C, renal disease, amyloidosis and antibiotics - Professor, Research team manager
Person
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Veronica Lindström
- Division of Clinical Chemistry and Pharmacology - Research engineer
- Cystatin C, renal disease, amyloidosis and antibiotics - Research engineer
Person
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Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate
Nakano, F. K., Åkesson, A., de Boer, J., Dedja, K., D’hondt, R., Haredasht, F. N., Björk, J., Courbebaisse, M., Couzi, L., Ebert, N., Eriksen, B. O., Dalton, R. N., Derain-Dubourg, L., Gaillard, F., Garrouste, C., Grubb, A., Jacquemont, L., Hansson, M., Kamar, N. & Legendre, C. & 17 others, , 2024 Dec, In: Scientific Reports. 14, 1, 26383.Research output: Contribution to journal › Article › peer-review
Open Access -
Different ways of diagnosing selective glomerular hypofiltration syndromes such as shrunken pore syndrome and the associated increase in mortality
Åkesson, A., Malmgren, L., Leion, F., Nyman, U., Christensson, A., Björk, J. & Grubb, A., 2024 Nov 19, In: Journal of Internal Medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
Estimating glomerular filtration in young people
Delanaye, P., Derain-Dubourg, L., Björk, J., Courbebaisse, M., Couzi, L., Gaillard, F., Garrouste, C., Grubb, A., Jacquemont, L., Hansson, M., Kamar, N., Legendre, C., Littmann, K., Mariat, C., Rostaing, L., Rule, A. D., Sundin, P.-O., Bökenkamp, A., Berg, U. & Åsling-Monemi, K. & 4 others, , 2024 Sept, In: Clinical Kidney Journal. 17, 9, p. fae261Research output: Contribution to journal › Article › peer-review
Open Access
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Variants of cystatin C
Andersson, F. (Researcher), Abrahamson, M. (PI) & Grubb, A. (Assistant supervisor)
2014/10/01 → …
Project: Dissertation
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Shrunken Pore Syndrome (SPS) - morbidity and mortality in a population with measured glomerular filtration rate (GFR)
Björk, J. (Researcher), Grubb, A. (PI), Christensson, A. (Researcher), Abrahamson, M. (Researcher), Nyman, U. (Researcher), Åkesson, A. (Researcher) & Lindström, V. (Researcher)
2018/01/01 → 2020/12/31
Project: Research