Cystatin C, renal disease, amyloidosis and antibiotics

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    EB-blocket, plan 2, Klinisk kemi, SUS

    22185 Lund


Unit profile


We have described the structure and function of human cystatin C and its gene. We have shown that the plasma level of cystatin C is the best marker for glomerular filtration rate, GFR, and that a new disorder, “Shrunken-Pore-Syndrome”, with a high prevalence and a very high mortality, can be identified my measuring cystatin C. We are studying the pathophysiology of the disorder and how to treat it. We have determined the mechanism by which a mutation in the cystatin C gene causes an amyloid deposition of the protein in brain arteries producing brain hemorrhage in young adults. The mechanism is similar to that occurring in other common amyloid disorders, e.g, Alzhemier´s and Parkinson´s disease. We develop substances interfering in this mechanism. We have produced new antibacterial and antiviral substances, based upon the structure of cystatin C, and continue to improve them. Some of the substances are active against bacterial strains resistent towards all presently available antibiotics.

UKÄ subject classification

  • Clinical Laboratory Medicine
  • Medicinal Chemistry
  • Urology and Nephrology

Free keywords

  • Amyloidosis
  • antibiotics
  • cerebral haemorrhage
  • creatinine
  • cystatin C
  • cystatins
  • eGFR
  • estimated GFR
  • GFR
  • glomerular filtration rate
  • kidney
  • renal

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations the last five years

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