Research output per year
Research output per year
Unit profile
Description
The overall objective of our research is to investigate how Type 2 Diabetes (T2D) associated environmental factors effects the islet hormone secretion with a specific focus on how impaired exocytosis is involved in the etiology of the disease. We investigate from a cell physiological perspective the regulation of insulin and glucagon secretion from the pancreatic beta – and alpha cells, respectively. We have a specific interest in how non-coding RNAs (ncRNAs) are involved in this regulation. Belonging to the group of ncRNAs are microRNAs (miRNA). The function of miRNAs is to suppress the expression of genes and we investigate specific miRNAs involved in the regulation of alpha- and beta-cell stimulus-secretion coupling and exocytosis. Ultimately, our research gives new insight into treatment and discovery strategies of T2D, and we anticipate our novel findings will be essential for future prediction, prevention and treatment of T2D.
Subject classification (UKÄ)
- Endocrinology and Diabetes
- Cardiology and Cardiovascular Disease
- Medical Genetics and Genomics (including Gene Therapy)
- Cell and Molecular Biology
Free keywords
- Type 2 diabetes
- exocytosis
- RNA
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Lena Eliasson
- Department of Clinical Sciences, Malmö
- Diabetes - Islet Cell Exocytosis - Research team manager, Principal investigator
- EXODIAB: Excellence of Diabetes Research in Sweden - Principal investigator
Person: Academic
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Jonathan LS Esguerra
- Diabetes - Islet Cell Exocytosis - Affiliated researcher
- EXODIAB: Excellence of Diabetes Research in Sweden - Researcher
Person
Research output
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Fish-hunting cone snail disrupts prey’s glucose homeostasis with weaponized mimetics of somatostatin and insulin
Yeung, H. Y., Ramiro, I. B. L., Andersen, D. B., Koch, T. L., Hamilton, A., Bjørn-Yoshimoto, W. E., Espino, S., Vakhrushev, S. Y., Pedersen, K. B., de Haan, N., Hipgrave Ederveen, A. L., Olivera, B. M., Knudsen, J. G., Bräuner-Osborne, H., Schjoldager, K. T., Holst, J. J. & Safavi-Hemami, H., 2024 Dec, In: Nature Communications. 15, 1, 6408.Research output: Contribution to journal › Article › peer-review
Open Access -
Apolipoprotein A-I priming via SR-BI and ABCA1 receptor binding upregulates mitochondrial metabolism to promote insulin secretion in INS-1E cells
Lyons, C. L., Cowan, E., Nilsson, O., Mohar, M., Peña-Martínez, P., Eliasson, L. & Lagerstedt, J. O., 2024 Nov, In: PLoS ONE. 19, 11 November, e0311039.Research output: Contribution to journal › Article › peer-review
Open Access -
IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion
Westholm, E., Karagiannopoulos, A., Kattner, N., Al-Selwi, Y., Merces, G., Shaw, J. A., Wendt, A. & Eliasson, L., 2024 Aug 19, In: iScience. 27, 9, 110767.Research output: Contribution to journal › Article › peer-review
Open Access
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Interorganisk kommunikation vid cystisk fibros-relaterad diabetes och dess relevans för förutsägelse och behandling av sjukdomen
Eliasson, L. (PI)
Swedish Child Diabetes Foundation
2025/03/12 → 2026/03/12
Project: Research
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Transcriptional regulation of pancreatic alpha cell differentiation
Bsharat, S. (Research student), Artner, I. (Supervisor) & Eliasson, L. (Assistant supervisor)
2021/10/01 → …
Project: Dissertation
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MicroRNA regulation of Alpha cell function
Westholm, E. (Researcher), Eliasson, L. (Supervisor), Karagiannopoulos, A. (Research student) & Wendt, A. (Assistant supervisor)
2020/09/01 → 2023/08/31
Project: Dissertation
Activities
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Insulin-like growth factor binding protein 7 reduces glucose stimulated insulin secretion and downregulates key beta cell transcription factors
Westholm, E. (Role not specified)
2022 Sept 21Activity: Talk or presentation › Presentation
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Manca Mohar
Lyons, C. (Joint first/primary/lead supervisor) & Eliasson, L. (Joint first/primary/lead supervisor)
2020 Sept → 2021 AprActivity: Examination and supervision › Supervision of masters students
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Hereditas (Journal)
Eliasson, L. (Role not specified)
2020 → …Activity: Publication peer-review and editorial work › Journal editor