Research output per year
Research output per year
Unit profile
Research
The department focuses on research that aims to develop gene therapy for hematopoietic cells using viral vectors. Hematopoiesis, in particular the genetic control of hematopoietic cell proliferation and differentiation is also studied in human cell cultures and transgenic mouse model systems.
Description
Dysfunctional blood cell development can have fatal consequences on human health, with implications for several key areas of modern medicine, including amongst others the broad research areas of oncology and immunology. The Division of Molecular Hematology (DMH) aims to generate new knowledge about the regulation of blood cell development by applying recent advances in stem cell technology, in order to dissect the molecular regulation of hematopoiesis. Our mission is to translate this information into clinical contexts to advance the full potential of regenerative medicine.
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Units
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Cell Reprogramming in Hematopoiesis and Immunity
Division of Molecular Medicine and Gene Therapy
Organisational unit: Research group
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Division of Molecular Medicine and Gene Therapy
Department of Laboratory Medicine
Organisational unit: Division
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Hematopoiesis and Gene Therapy
Division of Molecular Medicine and Gene Therapy
Organisational unit: Research group
Profiles
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Abdul Ghani Alattar
- Division of Molecular Medicine and Gene Therapy - Research engineer
- Stem Cells to Red Blood Cells - Research engineer
- Transfusion Medicine - Research engineer
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Research engineer
- LUCC: Lund University Cancer Centre - Doctoral student
Person
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Rita Alves
- Cell Reprogramming in Hematopoiesis and Immunity - Doctoral student
- Division of Molecular Medicine and Gene Therapy - Doctoral student
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Doctoral student
- LUCC: Lund University Cancer Centre - Doctoral student
Person
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Ervin Ascic
- Division of Molecular Medicine and Gene Therapy - Visiting research fellow
- Cell Reprogramming in Hematopoiesis and Immunity - Visiting research fellow
Person
Research output
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Activation of endogenous retroviruses during brain development causes an inflammatory response
Jönsson, M. E., Garza, R., Sharma, Y., Petri, R., Södersten, E., Johansson, J. G., Johansson, P. A., Atacho, D. A., Pircs, K., Madsen, S., Yudovich, D., Ramakrishnan, R., Holmberg, J., Larsson, J., Jern, P. & Jakobsson, J., 2021, In: EMBO Journal. 40, 9, p. e106423Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (SciVal) -
BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism
Luo, L., Sun, W., Zhu, W., Li, S., Zhang, W., Xu, X., Fang, D., Grahn, T. H. M., Jiang, L. & Zheng, Y., 2021 Feb, In: Cell Death and Disease. 12, 2, 169.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (SciVal) -
Bone marrow transplantation without myeloablative conditioning in a mouse model for Diamond-Blackfan anemia corrects the disease phenotype
Dahl, M., Warsi, S., Liu, Y., Debnath, S., Billing, M., Siva, K., Flygare, J. & Karlsson, S., 2021, In: Experimental Hematology. 99, p. 44-53.e2Research output: Contribution to journal › Article › peer-review
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Determining the role of EMP3 in erythropoiesis and cancer
Olsson, M. L., Flygare, J., Ilsley, M. & Alattar, A. G.
2020/02/24 → …
Project: Research
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Hematopoietic stem cell dynamics during regeneration
Rydström, A., Larsson, J., Bryder, D. & Miharada, K.
2019/04/01 → …
Project: Dissertation
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Defining Regulators of Human Hematopoietic Stem Cells using CRISPR/Cas9 Gene Targeting
Bäckström, A., Larsson, J. & Järås, M.
2018/05/01 → …
Project: Dissertation
Activities
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Unistem Day 2020
Göran Karlsson (Organiser), Christine Karlsson (Organiser), Paulina Pettersson (Organiser), Claire McKay (Organiser), Henrik Ahlenius (Organiser), Malin Parmar (Organiser), Mattias Magnusson (Organiser), Rebecca Warfvinge (Organiser), Sara Nolbrant (Speaker), Pia Johansson (Contributor), Diahann Atacho (Contributor), Shelby Shrigley (Contributor), Ulla Jarl (Contributor), Michael Sparrenius (Contributor), Bengt Mattsson (Contributor), Deirdre Hoban (Contributor), Alessandro Fiorenzano (Contributor), Jessica Giacomoni (Contributor), Fredrik Nilsson (Contributor), Edoardo Sozzi (Contributor), Anna Hammarberg (Contributor), Karolina Pircs (Contributor), Andreas Bruzelius (Contributor), Marcella Birtele (Contributor), Shayini Kidnapillai (Contributor), Efrain Cepeda-Prado (Contributor), Katharina Mikulik (Contributor), Raquel Garza (Contributor) & Petter Storm (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Supervision of PhD student: Sara Nolbrant
Malin Parmar (First/primary/lead supervisor), Agnete Kirkeby (Second supervisor), Carlos-Filipe Pereira (Commissioned member of Examining committee) & Laurent Roybon (Commissioned member of Examining committee)
2016 → 2020 Jan 31Activity: Examination and supervision › Supervision of PhD students
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Supervision of Ph.D. student Anja Nylander, M.D.
Martin L Olsson (First/primary/lead supervisor), Karina Vidovic (Joint second supervisor) & Johan Flygare (Joint second supervisor)
2016 May 1Activity: Examination and supervision › Supervision of PhD students
Prizes and distinction
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Roswell Park Outstanding Ph.D. Dissertation Award
Leigh, Nicholas (Recipient), 2016
Prize: Prize (including medals and awards)
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The role of S100A6 in Hematopoietic Stem Cell regulation
Tan Grahn, Hooi Min (Recipient), 2016 Nov 16
Prize: Prize (including medals and awards)