Research output per year
Research output per year
Unit profile
Research
Epilepsy is one of the most devastating neurological diseases, affecting at least 60 million people worldwide. But despite certain progress in antiepileptic drug developmental, available pharmacological treatments are only symptomatic, have side effects and fail to adequately control seizures in a third of patients. Recently, neuropeptides and neurotrophic factors emerged as strong regulators of synaptic transmission in the CNS, offering a potent tool to counteract the seizure activity. However, it is not clear yet what the role of these agents is in mechanisms of epileptogenesis. We do research to develop gene therapy strategies based on neuropeptides and neurotrophic factors. We also use optogenetics and chemogenetics as tools to investigate mechanisms of epileptogenesis with the aim to develop these techniques as possible therapeutic approach to suppress seizures.UKÄ subject classification
- Neurology
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Merab Kokaia
- Epilepsy Center - Head of office, Principal investigator
- Neurology, Lund - Professor
- Experimental Epilepsy Group - Project manager
- NanoLund: Centre for Nanoscience - Principal investigator
- LTH Profile Area: Nanoscience and Semiconductor Technology - Profile area member
- LU Profile Area: Light and Materials - Profile area member
Person
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Marco Ledri
- Epilepsy Center - Assistant researcher, Principal investigator
- Experimental Epilepsy Group - Research project participant
- Molecular Neurophysiology and Epilepsy group - Research team manager
Person
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Esbjörn Melin
- Epilepsy Center - Doctoral student
- Neurology, Lund - Research student
- Experimental Epilepsy Group - Research project participant
Person
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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
Canals, I., Comella-Bolla, A., Cepeda-Prado, E., Avaliani, N., Crowe, J. A., Oburoglu, L., Bruzelius, A., King, N., Pajares, M. A., Pérez-Sala, D., Heuer, A., Rylander Ottosson, D., Soriano, J. & Ahlenius, H., 2023, In: Brain Communications. 5, 3, p. 1-16 fcad158.Research output: Contribution to journal › Article › peer-review
Open Access -
Cell-specific switch for epileptiform activity: critical role of interneurons in the mouse subicular network
Wickham, J., Ledri, M., Andersson, M. & Kokaia, M., 2023, In: Cerebral Cortex. 33, 10, p. 6171-6183Research output: Contribution to journal › Article › peer-review
Open Access -
Neuronal activity dynamics in the dentate gyrus during early epileptogenesis
Berglind, F., Boulot, A., Gonzalez-Ramos, A., Melin, E., Bono, A., Sørensen, A. T. & Ledri, M., 2023, In: Epilepsy Research. 194, 107182.Research output: Contribution to journal › Article › peer-review
Open Access
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Gene therapy with precision targeting for epilepsy
Olle Engkvists stiftelse, Swedish Research Council
2022/01/01 → 2026/12/31
Project: Research
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Optogenetic control of neurotransmitter release from human stem cell progeny for Epilepsy
Gonzalez Ramos, A., Kokaia, M., Andersson, M. & Ledri, M.
2017/09/15 → …
Project: Dissertation
Activities
- 1 Organisation of conference
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Neuroscience Day 2021
Malin Parmar (Organiser), Martin Garwicz (Organiser), Anders Björklund (Organiser), Christine Ekdahl Clementson (Organiser), Bo Norrving (Member of programme committee), Åsa Petersén (Organiser), Oskar Hansson (Member of programme committee), MARIA COMPAGNO STRANDBERG (Member of programme committee), Paulina Pettersson (Organiser), Claire Wyart (Invited speaker), Markus Heilig (Invited speaker), Marie Carlen (Invited speaker), Ana Gonzalez Ramos (Presenter), Elna Dickson (Presenter), Emelie Andersson (Presenter), Kajsa Brolin (Presenter), Martino Avallone (Presenter), Nicholas Bechet (Presenter), Michael Ewers (Invited speaker), Magdalena Götz (Keynote/plenary speaker) & Daniella Ottosson (Chair)
2021 May 6Activity: Participating in or organising an event › Organisation of conference
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