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    Sölvegatan 17, BMC A12

    221 84 Lund


Unit profile


We study the regulation of hematopoietic stem cells in order to understand how signaling pathways, transcriptional mechanisms govern stem cell behavior to determine stem cell fate options. Integrative signaling and transcriptional networks act in concert to determine whether hematopoietic stem cells remain quiescent, proliferate and self-renew, expand through self-renewal, differentiate or undergo apoptosis. We study various regulators to determine how we can 1) expand stem cells 2) understand the pathogenesis of blood malignancies and genetic disorders of the blood system and 3) develop cell and gene therapies. Goals • Develop methods to expand hematopoietic stem cells and early progenitors to improve engraftment following blood and marrow transplantation. • Understand the pathogenesis of Diamond Blackfan anemia and develop mechanism-based therapies for this disorder, including gene therapy. • Develop curative gene therapy for the most common lysosomal storage disorder, Gaucher disease.

UKÄ subject classification

  • Cell and Molecular Biology

Free keywords

  • Hematopoiesis
  • hematopoietic stem cells
  • gene therapy

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or