• Visiting addressShow on map

    Medicon Village , Byggnad 404

    Lund

    Sweden

  • Postal addressShow on map

    Scheelevägen 2

    Lund

    Sweden

Unit profile

Research

Solid tumors are consistently less oxygenated than the normal tissues from which they arose. Associations between tumor hypoxia and aggressively malignant phenotypes are observed across a range of cancers. Clear cell renal cell carcinoma is characterized by a loss of the tumor suppressor gene VHL that leads to a constitutive hypoxic response. As such, it represents a model system for tumor hypoxia in general. In the current research project we aim identify and characterize the different cell types from which kidney cancer is thought to develop, and to characterize how they respond to loss of VHL. Filtration and selective transport of molecules represents a key function of the normal kidney. We are therefore exploring whether transport proteins might represent a particularly attractive source for identification of novel biomarkers for kidney cancer.

UKÄ subject classification

  • Cancer and Oncology
  • Cell and Molecular Biology

Free keywords

  • Kidney cancer
  • diagnostics
  • transporter proteins
  • hypoxia

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or