Ageing of the world’s population has amplified neurodegenerative disorders, of which Alzheimer’s disease (AD) and Parkinson’s disease (PD) are most common dementias. Both disorders are characterized by abnormal aggregation of proteins in brain. The molecular mechanism (or mechanisms) leading to the abnormal accumulation of ggregation of proteins remains unknown. We want to understand why abnormal protein aggregation begins and how these aggregated proteins (a-synuclein, amyloid-ß, and tau) may interact in vitro and in vivo combining advanced microscopy with synchrotron based micro- and nano-spectrocopic techniques.