Research output per year
Research output per year
Sölvegatan 19, BMC C13
221 84 Lund
Sweden
We are interested in the molecular connection between superantigens from S. aureus and the insulin signaling pathway in human adipocytes, and consequently the function of glucose and glycerol transporters. We are also investigating the nature of the interplay between leukemia cells and adipocytes. Leukemic stem cells have been shown to utilize the adipose tissue microenvironment to support their metabolism and help them evade chemotherapy. We want to elucidate what molecules are responsible for the induced lipolysis and how the lipid loaded leukemic cells persist chemotherapy, and if was can inhibit the interplay and use that in cancer therapy. To resolve these questions, we apply interdisciplinary approach by combining structural biology and microscopy.
The main objectives for Lindkvist laboratory are to make use of structural biology techniques, such as X-ray crystallography, and combine that with microscopy to reveal mechanisms of action in the metabolic systems in the human body. We have for many years been studying the role of bacterial toxins (superantigens) in the immune system, as well as the specificity of certain channels facilitating the transport of glucose and glycerol. More recent insights have generated an entirely new perspective suggesting that an altered microbiota can contribute to development of insulin resistance. But the molecular connection between altered microbiota and insulin resistance, and hence development of metabolic disorders, is still unclear. Yet, recently it was discovered that bacterial toxins (superantigens) cause rabbits to develop the hallmark symptoms of type 2 diabetes, including insulin resistance and glucose intolerance.
Person
Research output: Working paper/Preprint › Preprint (in preprint archive)
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Lindkvist, K. (PI)
2025/01/01 → 2028/12/31
Project: Research
Lindkvist, K. (PI)
Swedish Foundation for Strategic Research, SSF
2025/01/01 → 2028/12/31
Project: Research
Rebrova, E. M. (Contributor)
Activity: Other › Media participation
Säll Sernevi, J. (Commissioned member of Examining committee)
Activity: Examination and supervision › External Reviewer of PhD thesis/Opponent
Paulsson, K. M. (Examiner), Stenmark, P. (Examiner) & Lindkvist, K. (First/primary/lead supervisor)
Activity: Examination and supervision › External Reviewer of PhD thesis/Opponent