Research output per year
Research output per year
Unit profile
Description
Emma Hammarlund is Research Group Leader for this research group
What it takes to form multicellularity remains poorly understood – whether it’s in the shape of animals or tumors. We discuss whether the key components behind the rise of multicellularity are developmental, environmental, or ecological. To explore these key components, and their interaction, will advance our view on our origins. While the rise of animals is commonly studied with clues from Earth history (geology) and their development (biology), tumor biology can add unique real-time insight to the dynamics at a successful rise of ‘ugly’ multicellularity. And vice versa, insights from organismal evolution over geological time can provide a frame of reference to how we interrogate tumor evolution.
Research
In a transdisciplinary effort, we utilize both geobiology and tumor biology to explore the evolutionary roots to animal health and disease. One focus is the role that biological innovations like the cellular hypoxic response machineries have played for the rise of complex multicellularity. Another focus is the shared programs that unicellular organisms and single cancer cells utilize for metabolism, motility, and mediation of toxicity.
UKÄ subject classification
- Geosciences, Multidisciplinary
- Cell and Molecular Biology
- Cancer and Oncology
- Evolutionary Biology
- Developmental Biology
Free keywords
- Developmental evolutionary biology
- geobiology
- differentiation
- stemness
- HIF
- animal evolution
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Mikaela Ahlin
- Molecular Evolution - Doctoral student
- LUCC: Lund University Cancer Centre - Doctoral student
Person
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Etienne Baratchart
- Molecular Evolution - Postdoctoral fellow
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Postdoctoral fellow
Person
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Arthur Boffelli Castro
- Molecular Evolution - Doctoral student
- LUCC: Lund University Cancer Centre - Doctoral student
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Doctoral student
Person
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Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways
Gatenby, R. A., Luddy, K. A., Teer, J. K., Berglund, A., Freischel, A. R., Carr, R. M., Lam, A. E., Pienta, K. J., Amend, S. R., Austin, R. H., Hammarlund, E. U., Cleveland, J. L., Tsai, K. Y. & Brown, J. S., 2024 Jun, In: Medical Oncology. 41, 6, 135.Research output: Contribution to journal › Article › peer-review
Open Access -
MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma
Fredlund, E., Andersson, S., Hilgert, E., Monferrer, E., Álvarez-Hernán, G., Karakaya, S., Loontiens, S., Bek, J. W., Gregor, T., Lecomte, E., Magnusson, E., Miltenyte, E., Cabirol, M., Kyknas, M., Engström, N., Henriksson, M. A., Hammarlund, E., Rosenblum, J. S., Noguera, R., Speleman, F., & 2 others, 2024 Jun, In: Science Advances. 10, 25, eado1583.Research output: Contribution to journal › Article › peer-review
Open Access -
Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition
Gorji Bahri, G., Krishna, B. M., Hagerling, C., Orimo, A., Jirström, K., Papadakos, K. S. & Blom, A., 2024 Apr 13, In: Journal of Translational Medicine. 22, 351, p. 1-19 351.Research output: Contribution to journal › Article › peer-review
Open Access
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Den terapeutiska potentialen som döljer sig i den icke-slumpartade spridningen av neuroblastom
The Swedish Childhood Cancer Fund
2024/01/01 → 2027/06/30
Project: Research
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Decoding Cancer Cell and Immune Cell Crosstalk: Investigating Cancer in the Metastatic Niche
2023/02/27 → 2029/02/23
Project: Dissertation
Activities
- 1 Organisation of workshop/ seminar/ course
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UniStem Day 2024: Dissemination and outreach of stem cell science
Daniella Ottosson (Organiser), Mattias Magnusson (Organiser), Srisaiyini Kidnapillai (Organiser), Henrik Ahlenius (Organiser), Alexis Bento Luis (Organiser), Raquel Martinez Curiel (Organiser), Kerstin Laurin (Organiser), Paula Martos Salvo (Organiser), Moubani Das (Contributor), Markus Wendler (Contributor), Bala Mohan Sivani (Contributor), Germán Ramos Passarello (Contributor), Edoardo Sozzi (Contributor), María García Garrote (Contributor), Chimezie Harrison Umeano (Contributor), Ugonna Chidiebere Okeke (Contributor), Vivien Horvath (Contributor), Raquel Garza (Contributor), Anita Adami (Contributor), Laura Castilla-Vallmanya (Contributor), Patricia Gerdes (Contributor), Ninoslav Pandiloski (Contributor), Qianren Jin (Contributor), Claudia de Guidi (Contributor), Sara Palma Tortosa (Contributor), Jonas Fritze (Contributor), Linda I Jansson (Contributor), Laura Robles Rodriguez (Contributor), Enrico Pracucci (Contributor), Yu-Ping Shen (Contributor), Francesco Trovato (Contributor), Juliane Tampé (Contributor), Radhika Thakore (Contributor), Christina-Anastasia Stamouli (Contributor), Cristiana Pinto dos Santos Vaz (Contributor), Constanza Aretio (Contributor), Claire Piochon (Contributor), Efrain Cepeda-Prado (Contributor), Max-Michael de Jongh (Contributor), Maria Tsalkitzidou (Contributor), Jana Bonsberger (Contributor), Christopher Douse (Contributor), Fereshteh Dorazehi (Contributor), Symela Koutounidou (Contributor), Ulla Jarl (Contributor), Sara Corsi (Contributor), Andreas Bruzelius (Contributor), Bengt Mattsson (Contributor), Anna Hammarberg (Contributor), Mette Habekost (Contributor), Pavan Prabhala (Contributor), Tyra Bremborg (Contributor), Malavika Sreekumar Nair (Contributor), Perrine Burdeyron (Contributor), Marina Mazariegos (Contributor), Maria Björklund (Contributor), Isabel Hidalgo (Contributor), Alice Hägg (Invited speaker), Emma Hammarlund (Invited speaker), Sofie Mohlin (Invited speaker) & Marlene Oesterle (Contributor)
2024 Mar 22Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course