• Visiting addressShow on map

    Medicon Village , Byggnad 404

    Lund

    Sweden

  • Postal addressShow on map

    Scheelevägen 2

    Lund

    Sweden

Unit profile

Description

Daniel Bexell is Research Group Leader for this research group

Research

Our overall aims are to unravel mechanisms leading to metastasis and treatment resistance of childhood cancer neuroblastoma, and to test compounds targeting aggressive neuroblastoma. We have recently established and characterized several neuroblastoma orthotopic patient-derived xenografts (PDXs). These PDXs retain the genotype, phenotype, tumorigenic, and metastatic properties of the tumors from which they were derived, making them authentic models for studying and targeting neuroblastoma metastasis and resistance. Our projects encompass studies on basic tumor biology as well as translational and preclinical studies with the aim to find novel treatments. We perform molecular and functional studies of primary and metastatic tumor cells, as well as in vitro and in vivo drug testing using PDXs as model system. Discovery of novel strategies to inhibit treatment-resistant metastatic tumors can increase survival and decrease side effects for high-risk neuroblastoma patients.

UKÄ subject classification

  • Cell and Molecular Biology
  • Cancer and Oncology

Free keywords

  • Pediatric cancer
  • neuroblastoma
  • metastatis
  • treatment resistance

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations and top research areas from the last five years

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