Unit profile
Research
Our ultimate research goal is to find improved ways to treat patients with metastatic breast cancer. Although significant progress in treatment strategies has been made during the last decades, many breast cancer patients still relapse and to date metastatic breast cancer remains an incurable disease. We aim to identify the signalling pathways active in recurrent disease in order to study response to targeted therapeutics against such pathways and to better understand resistance mechanisms. Ongoing projects: 1. Identification of mechanisms that cause acquired resistance to endocrine therapy in metastatic breast cancer. 2. Study of the involvement of cancer stem cells in development of resistance to endocrine treatment. 3. Study of the downstream effectors in MYC driven triple negative breast tumours to find druggable targets in this elusive subtype of breast cancer. 4. Investigate tumour evolution and development of “liquid biopsies” as a surrogate for tumour biopsies.
Subject classification (UKÄ)
- Basic Cancer Research
- Cancer and Oncology
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations the last five years
Profiles
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Ana Bosch Campos
- Breastcancer-genetics
- Molecular therapeutics in breast cancer - Project manager
- LUCC: Lund University Cancer Centre - Member of research environment
- Breastcancer - Researcher
Person
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Gabriella Honeth
- Breastcancer-genetics - Associate researcher
- Molecular therapeutics in breast cancer - Project manager
- LUCC: Lund University Cancer Centre - Member of research environment
Person
Research output
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Fibrillarin-dependent 2′-O-methylation modulates RPS28 ribosome incorporation and oncogenic translation
Groza, P., Kumari, K., Esteva-Socias, M., Schott, J., Bhattarai, D. P., Sajkowska, J. J., Dasgupta, R., Peula, C., Destefanis, E., Williams, C., Marchand, V., Wikström, P., Wiberg, R., Campos, A. B., Gilthorpe, J. D., Pop, B., Mateus, A., Motorin, Y., Dassi, E. & Petzold, K. & 2 others, , 2026 Feb 28, In: Cancer Letters. 639, 218124.Research output: Contribution to journal › Article › peer-review
Open Access -
Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer
Davies, H. R., Black, D., Kvist, A., Sigurjónsdóttir, K., Bosch, A., Bowden, R., Memari, Y., Chen, Z., Rinaldi, G., Rosengren, F., Nacer, D. F., Veerla, S., Hohmann, L., Nordborg, N., Häkkinen, J., Vallon-Christersson, J., Borg, Å., Nik-Zainal, S. & Staaf, J., 2026 Feb 16, In: Communications medicine. 6, 1, 118.Research output: Contribution to journal › Article › peer-review
Open Access -
Dynamic methylation and expression of alternative promoters for oestrogen receptor alpha in cell line models of fulvestrant resistance
Albrecht, J., Müller, M., Hafstað, V., Kaminska, K., Vallon-Christersson, J., Honeth, G. & Persson, H., 2025, In: Molecular Oncology. 19, 1, p. 204-224Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active
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Epithelial ovarian cancer subtypes: early detection, clinical manifestations & role of the microenvironment
Rejmer, A. (Research student), Hedenfalk, I. (Supervisor), Asp, M. (Assistant supervisor), Honeth, G. (Assistant supervisor) & Martin de la Fuente, L. (Assistant supervisor)
2024/06/01 → 2032/06/01
Project: Dissertation
Activities
- 1 Participation in workshop/ seminar/ course
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State of the Art Bröstcancer, Malmö 2021
Ehinger, A. (Session chair), Loman, N. (Organiser), Klintman, M. (Member of programme committee), Bosch Campos, A. (Session chair), Lång, K. (Session chair) & Svensjö, T. (Session chair)
2021 Oct 21 → 2021 Oct 22Activity: Participating in or organising an event › Participation in workshop/ seminar/ course