Multidimensional microstructure imaging

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    Centralblocket, SUS, Lund, plan 4

    221 85 Lund

    Sweden

Unit profile

Research

In diffusion MRI (dMRI), images are sensitised to water diffusion by the application of magnetic field gradients. Cell membranes hinder the diffusional motion and thereby contribute to the contrast in dMRI. Thus, the diffusion of water molecules is used a probe of tissue microstructure. Data from dMRI is often analysed using diffusion tensor imaging (DTI), which yields image biomarkers that reflect cell density and the orientation coherence of tissue, in terms of the mean diffusivity (MD) and fractional anisotropy (FA), respectively. However, these metrics conflates multiple measures of the microstructure. In our group, we are developing a novel set of technologies for acquisition and analysis of dMRI that we collectively call multidimensional microstructure imaging (MMI). MMI takes advantage of our recent developments for dMRI that enables diffusion encoding by gradient waveforms that goes beyond previous strategies, such as so-called single diffusion encoding.

UKÄ subject classification

  • Cancer and Oncology

Free keywords

  • MRI
  • biophysical modelling
  • diffusion
  • microstructure

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations the last five years

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