Research output per year
Research output per year
- 1 - 50 out of 85 results
Search results
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2024
AβPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease
Zhang, Y. H., Sun, X. T., Guo, R. F., Feng, G. Y., Gao, H. L., Zhong, M. L., Tian, L. W., Qiu, Z. Y., Cui, Y. W., Li, J. Y. & Zhao, P., 2024 May, In: Matrix Biology. 129, p. 29-43 15 p.Research output: Contribution to journal › Article › peer-review
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2023
α-Synuclein induces deficiency in clathrin-mediated endocytosis through inhibiting synaptojanin1 expression
Song, D. Y., Yuan, L., Cui, N., Feng, C., Meng, L., Wang, X. H., Xiang, M., Liu, D., Wang, C., Zhang, Z., Li, J. Y. & Li, W., 2023 Nov, In: Journal of Neurochemistry. 167, 3, p. 461-484 24 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates
Anwer, D. M., Gubinelli, F., Kurt, Y. A., Sarauskyte, L., Jacobs, F., Venuti, C., Sandoval, I. M., Yang, Y., Stancati, J., Mazzocchi, M., Brandi, E., O'Keeffe, G., Steece-Collier, K., Li, J. Y., Deierborg, T., Manfredsson, F. P., Davidsson, M. & Heuer, A., 2023 May, In: PLoS ONE. 18, 5 MAY, e0284480.Research output: Contribution to journal › Article › peer-review
Open Access -
The cervical lymph node contributes to peripheral inflammation related to Parkinson’s disease
Liu, Z., Huang, Y., Wang, X., Li, J. Y., Zhang, C., Yang, Y. & Zhang, J., 2023, In: Journal of Neuroinflammation. 20, 1, 93.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Cryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process
Gao, X., Fu, Y., Sun, S., Gu, T., Li, Y., Sun, T., Li, H., Du, W., Suo, C., Li, C., Gao, Y., Meng, Y., Ni, Y., Yang, S., Lan, T., Sai, S., Li, J., Yu, K., Wang, P. & Ding, C., 2022 Dec, In: Nature Communications. 13, 1, 5407.Research output: Contribution to journal › Article › peer-review
Open Access -
Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
Lv, Y. Q., Yuan, L., Sun, Y. V., Dou, H. W., Su, J. H., Hou, Z. P., Li, J. Y. & Li, W., 2022 Dec, In: Translational Neurodegeneration. 11, 14.Research output: Contribution to journal › Article › peer-review
Open Access -
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein
Reimer, L., Haikal, C., Gram, H., Theologidis, V., Kovacs, G., Ruesink, H., Baun, A., Nielsen, J., Otzen, D. E., Li, J. Y. & Jensen, P. H., 2022 Dec, In: Scientific Reports. 12, 3737.Research output: Contribution to journal › Article › peer-review
Open Access -
Association between Parkinson’s Disease and Diabetes Mellitus: From Epidemiology, Pathophysiology and Prevention to Treatment
Yu, H., Sun, T., He, X., Wang, Z., Zhao, K., An, J., Wen, L., Li, J. Y., Li, W. & Feng, J., 2022 Nov 16, In: Aging and Disease. 13, 6, p. 1591-1605 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure
Brandi, E., Torres-Garcia, L., Svanbergsson, A., Haikal, C., Liu, D., Li, W. & Li, J. Y., 2022 Aug 26, In: Frontiers in Aging Neuroscience. 14, 910988.Research output: Contribution to journal › Article › peer-review
Open Access -
Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
Bachiller, S., Hidalgo, I., Garcia, M. G., Boza-Serrano, A., Paulus, A., Denis, Q., Haikal, C., Manouchehrian, O., Klementieva, O., Li, J. Y., Pronk, C. J., Gouras, G. K. & Deierborg, T., 2022 Jun 15, In: Journal of Neuroinflammation. 19, 151.Research output: Contribution to journal › Article › peer-review
Open Access -
Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease
Martinsson, I., Quintino, L., Garcia, M. G., Konings, S. C., Torres-Garcia, L., Svanbergsson, A., Stange, O., England, R., Deierborg, T., Li, J., Lundberg, C. & Gouras, G. K., 2022, In: Frontiers in Aging Neuroscience. 14, p. 1-16 946297.Research output: Contribution to journal › Article › peer-review
Open Access -
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
Torres-Garcia, L., Domingues, J. M. P., Brandi, E., Haikal, C., Mudannayake, J. M., Brás, I. C., Gerhardt, E., Li, W., Svanbergsson, A., Outeiro, T. F., Gouras, G. K. & Li, J. Y., 2022, In: Scientific Reports. 12, p. 1-11 2987.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions
Liu, D., Guo, J. J., Su, J. H., Svanbergsson, A., Yuan, L., Haikal, C., Li, W., Gouras, G. & Li, J. Y., 2021 Dec, In: Translational Neurodegeneration. 10, 20.Research output: Contribution to journal › Article › peer-review
Open Access -
The bacterial amyloids phenol soluble modulins from staphylococcus aureus catalyze alpha-synuclein aggregation
Haikal, C., Pascual, L. O., Najarzadeh, Z., Bernfur, K., Svanbergsson, A., Otzen, D. E., Linse, S. & Li, J. Y., 2021 Nov 1, In: International Journal of Molecular Sciences. 22, 21, 11594.Research output: Contribution to journal › Article › peer-review
Open Access -
Coordinated bi-directional trafficking of synaptic vesicle and active zone proteins in peripheral nerves
Juranek, J. K., Mukherjee, K., Jahn, R. & Li, J. Y., 2021 Jun 25, In: Biochemical and Biophysical Research Communications. 559, p. 92-98 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer’s Disease
Paulus, A., Engdahl, A., Yang, Y., Boza Serrano, A., Bachiller, S., Torres-Garcia, L., Svanbergsson, A., Garcia, M., Keppler Gouras, G., Li, J-Y., Deierborg, T. & Klementieva, O., 2021 Mar 26, In: International Journal of Molecular Sciences. 22, 7, 3430.Research output: Contribution to journal › Article › peer-review
Open Access -
Mörka Neuron och Mobiltelefoner: Dedicerad till en 90-årig man, Arne Brun i Lund
Persson, B. R., Blennow, C., Brun, A., Eberhardt, J., Grafström, G., Malmgren, L., Nittby-Redenbrant, H., Salford, L. & Strömblad, S., 2021 Mar 7, In: Acta Scientiarum Lundensia. 2021, 001, p. 1-23Research output: Contribution to journal › Article › peer-review
File114 Downloads (Pure) -
Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease
Ding, X. B., Wang, X. X., Xia, D. H., Liu, H., Tian, H. Y., Fu, Y., Chen, Y. K., Qin, C., Wang, J. Q., Xiang, Z., Zhang, Z. X., Cao, Q. C., Wang, W., Li, J. Y., Wu, E., Tang, B. S., Ma, M. M., Teng, J. F. & Wang, X. J., 2021 Mar, In: Nature Medicine. 27, 3, p. 411-418 8 p.Research output: Contribution to journal › Article › peer-review
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Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis
Guo, J. J., Yue, F., Song, D. Y., Bousset, L., Liang, X., Tang, J., Yuan, L., Li, W., Melki, R., Tang, Y., Chan, P., Guo, C. & Li, J. Y., 2021 Jan, In: Cell Death and Disease. 12, 1, 81.Research output: Contribution to journal › Article › peer-review
Open Access -
FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation
Svanbergsson, A., Ek, F., Martinsson, I., Rodo, J., Liu, D., Brandi, E., Haikal, C., Torres-Garcia, L., Li, W., Gouras, G., Olsson, R., Björklund, T. & Li, J-Y., 2021, In: Neurotherapeutics. 18, 3, p. 1692-1709Research output: Contribution to journal › Article › peer-review
Open Access -
Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation
Elabi, O., Gaceb, A., Carlsson, R., Padel, T., Soylu-Kucharz, R., Cortijo, I., Li, W., Li, J. Y. & Paul, G., 2021, In: Scientific Reports. 11, 1, 1120.Research output: Contribution to journal › Article › peer-review
Open Access -
Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease
Gou, D. H., Huang, T. T., Li, W., Gao, X. D., Haikal, C., Wang, X. H., Song, D. Y., Liang, X., Zhu, L., Tang, Y., Ding, C. & Li, J. Y., 2021, In: Redox Biology. 38, 101795.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson’s Disease and Related Diseases
Sun, Y., Guo, C., Yuan, L., Li, W., Wang, Z. Y., Yue, F. & Li, J. Y., 2020 Feb 7, In: Frontiers in Neuroscience. 14, 63.Research output: Contribution to journal › Article › peer-review
Open Access -
A comparison of AAV-vector production methods for gene therapy and preclinical assessment
Davidsson, M., Negrini, M., Hauser, S., Svanbergsson, A., Lockowandt, M., Tomasello, G., Manfredsson, F. P. & Heuer, A., 2020, In: Scientific Reports. 10, 1, 21532.Research output: Contribution to journal › Article › peer-review
Open Access -
Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
Wang, X. J., Ma, M. M., Zhou, L. B., Jiang, X. Y., Hao, M. M., Teng, R. K. F., Wu, E., Tang, B. S., Li, J. Y., Teng, J. F. & Ding, X. B., 2020, In: Nature Communications. 11, 1, 934.Research output: Contribution to journal › Article › peer-review
Open Access -
Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease
Stan, T. L., Soylu-Kucharz, R., Burleigh, S., Prykhodko, O., Cao, L., Franke, N., Sjögren, M., Haikal, C., Hållenius, F. & Björkqvist, M., 2020, In: Scientific Reports. 10, 1, 18270.Research output: Contribution to journal › Article › peer-review
Open Access -
No symphony without bassoon and piccolo: Changes in synaptic active zone proteins in Huntington's disease
Huang, T. T., Smith, R., Bacos, K., Song, D. Y., Faull, R. M., Waldvogel, H. J. & Li, J. Y., 2020, In: Acta Neuropathologica Communications. 8, 1, 77.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease
Vaikath, N. N., Erskine, D., Morris, C. M., Majbour, N. K., Vekrellis, K., Li, J. Y. & El-Agnaf, O. M. A., 2019 Oct, In: Neuropathology and Applied Neurobiology. 45, 6, p. 597-608 12 p.Research output: Contribution to journal › Article › peer-review
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Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice
Xu, S. F., Zhang, Y. H., Wang, S., Pang, Z. Q., Fan, Y. G., Li, J. Y., Wang, Z. Y. & Guo, C., 2019 Feb 1, In: Redox Biology. 21, 101090.Research output: Contribution to journal › Article › peer-review
Open Access -
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
Szegő, É. M., Dominguez-Meijide, A., Gerhardt, E., König, A., Koss, D. J., Li, W., Pinho, R., Fahlbusch, C., Johnson, M., Santos, P., Villar-Piqué, A., Thom, T., Rizzoli, S., Schmitz, M., Li, J., Zerr, I., Attems, J., Jahn, O. & Outeiro, T. F., 2019, In: Cell Reports. 28, 1, p. 65-77.e6Research output: Contribution to journal › Article › peer-review
Open Access -
Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
Wu, J-Z., Ardah, M., Haikal, C., Svanbergsson, A., Diepenbroek, M., Vaikath, N. N., Li, W., Wang, Z-Y., Outeiro, T. F., El-Agnaf, O. M. & Li, J-Y., 2019, In: Translational Neurodegeneration. 8, 18.Research output: Contribution to journal › Article › peer-review
Open Access -
Exosomes in Parkinson's Disease: Current Perspectives and Future Challenges
Yuan, L. & Li, J. Y., 2019, In: ACS Chemical Neuroscience. 10, 2, p. 964–972Research output: Contribution to journal › Article › peer-review
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2018
Brain pericyte activation occurs early in Huntington's disease
Padel, T., Roth, M., Gaceb, A., Li, J. Y., Björkqvist, M. & Paul, G., 2018 Jul 1, In: Experimental Neurology. 305, p. 139-150 12 p.Research output: Contribution to journal › Article › peer-review
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Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease
Chen, Q. Q., Haikal, C., Li, W., Li, M. T., Wang, Z. Y. & Li, J. Y., 2018 Jun 30, In: Translational Neurodegeneration. 7, 1, 13.Research output: Contribution to journal › Article › peer-review
Open Access -
2D polarization imaging as a low-cost fluorescence method to detect α-synuclein aggregation ex vivo in models of Parkinson’s disease
Camacho, R., Täuber, D., Hansen, C., Shi, J., Bousset, L., Melki, R., Li, J-Y. & Scheblykin, I., 2018, In: Communications Biology. 1, 157 .Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease
Chumarina, M., Azevedo, C., Bigarreau, J., Vignal, C., Kim, K. S., Li, J-Y. & Roybon, L., 2017 Mar 1, In: Stem Cell Research. 19, p. 17-20 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease
Majbour, N. K., Chiasserini, D., Vaikath, N. N., Eusebi, P., Tokuda, T., van de Berg, W. D. J., Parnetti, L., Calabresi, P. & El-Agnaf, O. M. A., 2017 Jan 10, In: Scientific Reports. 7, 40263.Research output: Contribution to journal › Article › peer-review
Open Access -
Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease
Zhong, C. B., Chen, Q. Q., Haikal, C., Li, W., Svanbergsson, A., Diepenbroek, M. & Li, J. Y., 2017, In: Neuroscience Bulletin. 33, 5, p. 483-492Research output: Contribution to journal › Article › peer-review
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2016
Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression
Majbour, N. K., Vaikath, N. N., Eusebi, P., Chiasserini, D., Ardah, M., Varghese, S., Haque, M. E., Tokuda, T., Auinger, P., Calabresi, P., Parnetti, L. & El-Agnaf, O. M. A., 2016 Oct 1, In: Movement Disorders. 31, 10, p. 1535-1542 8 p.Research output: Contribution to journal › Article › peer-review
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Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain.
LI, WEN., Englund, E., Widner, H., Mattsson, B., van Westen, D., Lätt, J., Rehncrona, S., Brundin, P., Björklund, A., Lindvall, O. & Li, J-Y., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 23, p. 6544-6549 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.
Majbour, N. K., Vaikath, N. N., van Dijk, K. D., Ardah, M. T., Varghese, S., Vesterager, L. B., Montezinho, L. P., Poole, S., Safieh-Garabedian, B., Tokuda, T., Teunissen, C. E., Berendse, H. W., van de Berg, W. D. J. & El-Agnaf, O. M. A., 2016, In: Molecular Neurodegeneration. 11, 1, 7.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Altered Sensory Experience Exacerbates Stable Dendritic Spine and Synapse Loss in a Mouse Model of Huntington's Disease.
Murmu, R., Li, W., Szepesi, Z. & Li, J-Y., 2015, In: The Journal of Neuroscience. 35, 1, p. 287-298Research output: Contribution to journal › Article › peer-review
File63 Downloads (Pure) -
By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.
Guan, P-P., Yu, X., Guo, J-J., Wang, Y., Wang, T., Li, J-Y., Konstantopoulos, K., Wang, Z-Y. & Wang, P., 2015, In: Oncotarget. 6, 11, p. 9140-9159Research output: Contribution to journal › Article › peer-review
Open AccessFile177 Downloads (Pure) -
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
Vaikath, N. N., Majbour, N. K., Paleologou, K. E., Ardah, M. T., van Dam, E., van de Berg, W. D. J., Forrest, S. L., Parkkinen, L., Gai, W-P., Hattori, N., Takanashi, M., Lee, S-J., Mann, D. M. A., Imai, Y., Halliday, G. M., Li, J-Y. & El-Agnaf, O. M. A., 2015, In: Neurobiology of Disease. 79, p. 81-99Research output: Contribution to journal › Article › peer-review
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Plaque-associated lipids in Alzheimer's diseased brain tissue visualized by nonlinear microscopy.
Kiskis, J., Fink, H., Nyberg, L., Thyr, J., Li, J-Y. & Enejder, A., 2015, In: Scientific Reports. 5, 13489.Research output: Contribution to journal › Article › peer-review
Open AccessFile216 Downloads (Pure) -
The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.
Roybon, L., Mastracci, T. L., Li, J., Stott, S., Leiter, A. B., Sussel, L., Brundin, P. & Li, J-Y., 2015, In: PLoS ONE. 10, 6, e0128035.Research output: Contribution to journal › Article › peer-review
Open AccessFile220 Downloads (Pure) -
2014
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.
Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Li, W., Björklund, T., Wang, Z-Y., Roybon, L., Melki, R. & Li, J-Y., 2014, In: Acta Neuropathologica. 128, 6, p. 805-820Research output: Contribution to journal › Article › peer-review
File732 Downloads (Pure) -
Intracellular Nogo-A facilitates initiation of neurite formation in mouse midbrain neurons in vitro.
Kurowska, Z., Brundin, P., Schwab, M. E. & Li, J-Y., 2014, In: Neuroscience. 256, p. 456-466Research output: Contribution to journal › Article › peer-review
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Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
Aldrin-Kirk, P., Davidsson, M., Holmqvist, S., Li, J-Y. & Björklund, T., 2014, In: PLoS ONE. 9, 7, e100869.Research output: Contribution to journal › Article › peer-review
Open AccessFile349 Downloads (Pure) -
Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis.
Sun, T-S., Ju, X., Gao, H-L., Wang, T., Thiele, D. J., Li, J-Y., Wang, Z-Y. & Ding, C., 2014, In: Nature Communications. 5, 5550.Research output: Contribution to journal › Article › peer-review
File524 Downloads (Pure)