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Neural stem cells

Unit profile

Research

Reprogramming somatic cells to induced pluripotent stem (iPS) cells and directed differentiation opens up for studies on neural cells from patients. The Falk group is focusing on fundamental questions in early human neurogenesis. We build cellular models of the healthy and diseased human brain using reprogrammed patient cells. We derive patient specific iPS cells that are further differentiated into patient specific neuroepithelial stem (NES) cells or into 3D brain organoids. We use the cellular models to study proliferation, self-renewal, and differentiation potential as well as the maturation and function of derived neurons to uncover disease mechanisms. The Neural Stem Cells lab is also driving translational projects investigating the regenerative potential of iPS cell derived neural cells in preclinical models with the aim to create ATMPs to take iPS derived cell to clinic. We have derived one of few clinical compliant GMP iPS cell lines that we have banked in a master bank.

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Collaborations the last five years

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  • An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines

    Wu, S., Chandel, S., Bryzgalova, G., Efstathopoulos, P., Blust, K., Zhao, C., Erbil, E., Falk, A., Hedhammar, M., Berggren, P. O. & Lanner, F., 2026 May, In: Stem Cell Reports. 21, 5, 102892.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • AI-driven Quality Control of cell-based ATMPs: Automated, Accurate, and Affordable

    Magnusson, R., Hägg, A., Twohig, D., Savchenko, E., Ghosheh, N., Melguizo-Sanchis, D., Falk, A. & Synnergren, J., 2026, In: Cytotherapy. 28, 7, 102135.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Toward standardized iPSC testing: Insights from a multi-year international Quality Assessment Round

    Hägg, A., Wood, R., Mochizuki, A. L., Abberton, K., Abranches, E., Alvarez-Palomo, B., Baptista, R., Quintanilha Barbosa, R. A., Barry, J., Carvalho, A. B., Bennaceur Griscelli, A., Campos de Carvalho, A. C., Chaker, D., Chang, H., Choi, H. Y., Codinach, M., Arán Corbella, B., Cowan, S., Dickerson, S. J. & Elwood, N. & 64 others, Fan, X., Feyeux, M., Forrester, M., Gaffney, A., Guilbert, S. M., Ha, H.-Y., Hirst, A. J., Hunter, A. L., Jamieson, L. G., Judson, R. N., Kanemura, Y., Kasai-Brunswick, T. H., Kim, J.-H., Kim, H., Kintali, M., Krishnan, S., Kuebler, B., Lau, C. Y., Li, W., Mack, A., MacLeod, M. R., Madrid, M., Mamiya, H., Manache-Alberici, L., Mărginean, D., Mentre, O., Morgan, S. L., Mountford, J., Munir, H., Ng, S. H. S., Ogawa, H., Oh, S., Ohara, H., Oono, K., Park, N., Pereira, L. V., Pereira da Silva Bezerra, I., Podovei, A. R., Querol, S., Raje, J., Raya, A., Sakamoto, S., Sarafian, R., Schmit, K., Selvitella, S., Singh, G., Smart, M. J. K., Song, J., Stacey, G., Sullivan, S., Sumida, M., Terrenoire, C., Tian, P., Uhlin, E., Vaquero, J. M. A., Veiga, A., Vicky Wang, J. W., Warre-Cornish, K., Wood, J., Yamamoto, A., Zhang, G., Hikichi, T., Turner, M. & Falk, A., 2026, In: Stem Cell Reports. 21, 4, 102857.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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