The immune system keeps us healthy and upon infection, its activity is upregulated in a strictly controled manner (i.e. inflammation) to eradicate invading pathogens. Excessive and long-standing inflammation cause tissue injury, subsequently resulting in remodeling (fibrosis), vulnerability to acquire infections, and respiratory failure. In the project, we characterize key mechanisms of importance to limit airway tissue damage and its consequences in diseases such as ARDS, COPD, pulmonary fibrosis, and asthma. Both experimental models as well as clinical samples are investigated.