Research output per year
Research output per year
Unit profile
Research
Diana Karpman's project focuses on the pathogenesis of renal diseases and the infectious, inflammatory and prothrombotic mechanisms leading to acute and chronic renal failure. Novel mechanisms of disease propagation via blood-borne and cell-derived microvesicles as well as complement and kinin system activation are investigated. The diseases investigated are enterohemorrhagic Escherichia coli (EHEC) infection, hemolytic uremic syndrome, complement-mediated renal disease and vasculitis. Mechanisms by which tissue damage is induced are investigated to define the bacterial and host components causing disease. Defining mechanisms of complement and kinin system activation based on genetic and functional assays may explain why patients are prone to thrombosis and inflammation promoting progression of kidney disease. Ultimately, we aim to develop specific treatments to prevent the spread of bacterial virulence factors and neutralize detrimental activation of the complement and kinin systems.
UKÄ subject classification
- Pediatrics
- Urology and Nephrology
- Immunology in the medical area
Free keywords
- Hemolytic uremic syndrome
- vasculitis
- microvesicles
- Shiga toxin
- kidney
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Ida Arvidsson
- Paediatrics (Lund) - Assistant researcher
- Pediatric Nephrology - Assistant researcher
Person
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Niklas Friberg Hed
- Paediatrics (Lund) - Doctoral student
- Pediatric Nephrology - Doctoral student
Person
Research output
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Hypoaldosteronism due to a novel SEC61A1 variant successfully treated with fludrocortisone
Karpman, D., Lindström, M. L., Möller, M., Ivarsson, S., Kristoffersson, A. C., Bekassy, Z., Fogo, A. B. & Elfving, M., 2024 Aug, In: Clinical Kidney Journal. 17, 8, sfae213.Research output: Contribution to journal › Article › peer-review
Open Access -
Ophthalmic manifestations in children with tuberous sclerosis complex
Öhnell, H. M., Kjellström, U., Eklund, E., Pearsson, K., Bekassy, Z. & Gränse, L., 2024 Jun, In: Acta Ophthalmologica. 102, 4, p. 421-427 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Complement dysregulation associated with a genetic variant in factor H-related protein 5 in atypical hemolytic uremic syndrome
Aradottir, S. S., Kristoffersson, A.-C., Linnér, E. & Karpman, D., 2024, In: Pediatric Nephrology. 39, 4, p. 1105-1111 7 p.Research output: Contribution to journal › Article › peer-review
Open Access
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Disease mechanisms and treatment strategies in E. coli O157:H7 infection
Wendler, M. (Research student), Karpman, D. (Supervisor) & Arvidsson, I. (Assistant supervisor)
2023/03/01 → …
Project: Dissertation
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Congenital hydronephrosis – impact of prenatal diagnostics and follow-up procedures in childhood
Malmström, T. (Researcher), Salö, M. (Assistant supervisor), Stenström, P. (Supervisor), Bekassy, Z. (Assistant supervisor) & Röckert Tjernberg, A. (Assistant supervisor)
2021/11/01 → …
Project: Research
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Studies of the pathogenesis of complement-mediated renal disease
Aradóttir, S. (PI)
2015/06/10 → …
Project: Research
Activities
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Amsterdam Vesicle Center EV Flow Cytometry Summer School
Wendler, M. (Contributor)
2024 Jul 8 → 2024 Jul 12Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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UniStem Day 2024: Dissemination and outreach of stem cell science
Ottosson, D. (Organiser), Magnusson, M. (Organiser), Kidnapillai, S. (Organiser), Ahlenius, H. (Organiser), Luis, A. B. (Organiser), Martinez Curiel, R. (Organiser), Laurin, K. (Organiser), Martos Salvo, P. (Organiser), Das, M. (Contributor), Wendler, M. (Contributor), Sivani, B. M. (Contributor), Ramos Passarello, G. (Contributor), Sozzi, E. (Contributor), García Garrote, M. (Contributor), Harrison Umeano, C. (Contributor), Okeke, U. C. (Contributor), Horvath, V. (Contributor), Garza, R. (Contributor), Adami, A. (Contributor), Castilla-Vallmanya, L. (Contributor), Gerdes, P. (Contributor), Pandiloski, N. (Contributor), Jin, Q. (Contributor), de Guidi, C. (Contributor), Palma Tortosa, S. (Contributor), Fritze, J. (Contributor), Jansson, L. I. (Contributor), Robles Rodriguez, L. (Contributor), Pracucci, E. (Contributor), Shen, Y.-P. (Contributor), Trovato, F. (Contributor), Tampé, J. (Contributor), Thakore, R. (Contributor), Stamouli, C.-A. (Contributor), Pinto dos Santos Vaz, C. (Contributor), Aretio, C. (Contributor), Piochon, C. (Contributor), Cepeda-Prado, E. (Contributor), de Jongh, M.-M. (Contributor), Tsalkitzidou, M. (Contributor), Bonsberger, J. (Contributor), Douse, C. (Contributor), Dorazehi, F. (Contributor), Koutounidou, S. (Contributor), Jarl, U. (Contributor), Corsi, S. (Contributor), Bruzelius, A. (Contributor), Mattsson, B. (Contributor), Hammarberg, A. (Contributor), Habekost, M. (Contributor), Prabhala, P. (Contributor), Bremborg, T. (Contributor), Nair, M. S. (Contributor), Burdeyron, P. (Contributor), Mazariegos, M. (Contributor), Björklund, M. (Contributor), Hidalgo, I. (Contributor), Hägg, A. (Invited speaker), Hammarlund, E. (Invited speaker), Mohlin, S. (Invited speaker) & Oesterle, M. (Contributor)
2024 Mar 22Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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11th VTEC International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections
Wendler, M. (Participant)
2023 May 7 → 2023 May 10Activity: Participating in or organising an event › Participation in conference