Research output per year
Research output per year
Unit profile
Description
Magnus Abrahamson is Research Group Leader for this research groupResearch
The aim of the the Protease Inhibitor Group is to elucidate how an important class of proteolytic enzymes, the cysteine proteases, are regulated in health and disease in order to understand how they can be targetted pharmacologically. Natural inhibitors of cysteine proteases are normally small proteins with structures complementary to the substrate binding clefts of their target enzymes. Such inhibitors are studied with respect to structure, function and biological activity in cell culture systems. A specific focus is on cancer research, to address the role of cystatins as markers and tumour suppressors. Another is to study cystatin C as a marker for kidney function and a third to reveal the mechanism leading to amyloidosis and brain haemorrhage due to aggregation of the inhibitor cystatin C. The work also includes research about proteases/inhibitors of pathogenic bacteria and parasites such as S. aureus , P. gingivalis and T. cruzi, and their interplay with host defense systems.UKÄ subject classification
- Clinical Laboratory Medicine
- Cell and Molecular Biology
- Cancer and Oncology
Free keywords
- Proteases
- proteinases
- inhibitors
- enzymes
- protein structure
- enzymology
- kidney
- inflammation
- proteolytic
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Magnus Abrahamson
- Division of Clinical Chemistry and Pharmacology - Senior lecturer
- Protease Inhibitor Research - Research team manager
- LUCC: Lund University Cancer Centre - Principal investigator
- EpiHealth: Epidemiology for Health - Researcher
Person
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Freddi Andersson
- Division of Clinical Chemistry and Pharmacology - Doctoral student
- Protease Inhibitor Research - Doctoral student
- LUCC: Lund University Cancer Centre - Doctoral student
Person
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Jenny Apelqvist
- Division of Clinical Chemistry and Pharmacology - Doctoral student, Specialty registrar
- Protease Inhibitor Research - Doctoral student, Specialty registrar
- LUCC: Lund University Cancer Centre - Doctoral student
Person
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An explorative study of inflammation-related proteins associated with kidney injury in male heat-stressed workers
Hansson, E., Broberg, K., Wijkström, J., Glaser, J., Gonzalez-Quiroz, M., Ekström, U., Abrahamson, M. & Jakobsson, K., 2023 Feb, In: Journal of Thermal Biology. 112, 103433.Research output: Contribution to journal › Article › peer-review
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Babesia divergens Shows Equal Predilection for Human ABO Blood Types in an In Vitro Erythrocyte Preference Assay.
Tijani, M. K., Danielsson, L., Storry, J. R., Olsson, M. L. & Persson, K. E. M., 2023 Jun 5, In: Pathogens. 12, 6, p. 1-10Research output: Contribution to journal › Article › peer-review
Open Access -
The complexity of kidney disease and diagnosing it - Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
Malmgren, L., Öberg, C., den Bakker, E., Leion, F., Siódmiak, J., Åkesson, A., Lindström, V., Herou, E., Dardashti, A., Xhakollari, L., Grubb, G., Strevens, H., Abrahamson, M., Helmersson-Karlqvist, J., Magnusson, M., Björk, J., Nyman, U., Ärnlöv, J., Ridefeldt, P., Åkerfeldt, T., & 18 others, 2023, In: Journal of Internal Medicine. 293, 3, p. 293-308Research output: Contribution to journal › Review article › peer-review
Open Access
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Prehospital triage at stroke
Wasselius, J., Esbjörnsson, M., Andsberg, G., Höglund, P. & Hansen, B.
Project: Research
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Shrunken Pore Syndrome (SPS) - morbidity and mortality in a population with measured glomerular filtration rate (GFR)
Björk, J., Grubb, A., Christensson, A., Abrahamson, M., Nyman, U., Åkesson, A. & Lindström, V.
2018/01/01 → 2020/12/31
Project: Research
Activities
- 2 Participation in workshop/ seminar/ course
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Cellbiologi-BIMA15
Hanna Wallin (Organiser) & Karina Vidovic (Organiser)
2018 Sept 25 → 2018 Dec 10Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Cellbiologi-BIMA15
Hanna Wallin (Organiser), Freddi Andersson (Organiser) & Karina Vidovic (Organiser)
2017 Oct 2 → 2017 Dec 2Activity: Participating in or organising an event › Participation in workshop/ seminar/ course