• Visiting addressShow on map

    Sölvegatan 19, BMC B12

    221 84 Lund

    Sweden

  • Postal addressShow on map

    Box 118

    221 00 Lund

    Sweden

Unit profile

Research

Proteins are the machinery of the cell, responsible for executing the functions essential for cells to operate, survive, differentiate and divide. In hematopoiesis, the proteomic make-up of blood stem cells and progenitors can regulate their cell fate and susceptibility to initiation as well as progression of leukemia. The broad interest of our group lies in understanding the molecular differences between fetal and adult hematopoiesis. By using in-depth mass spectrometry-based quantitative proteomics to monitor protein levels in a comprehensive and quantitative manner, our ongoing research aims at defining the fetal- and adult-specific proteomic programs that regulate normal and malignant hematopoiesis. Future work will include detailed proteomic profiling of ontogeny-specific leukemic features, investigation of the mechanistic details of hematopoietic stem cell plasticity, as well as specific types of post-translational modifications of particular importance in early hematopoiesis.

Description

Jenny Hansson is Research Group Leader for this research group

UKÄ subject classification

  • Cancer and Oncology

Free keywords

  • Hematopoieisis
  • stem cell
  • leukemia
  • proteomics
  • mass spectrometry

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations and top research areas from the last five years

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