Research output per year
Research output per year
Unit profile
Research
Hemolysis of erythrocytes releases high levels of cell-free hemoglobin and its metabolites, which are potentially dangerous molecules contributing to tissue and cell damage via redox-reactions. Our research aim to characterize these pathophysiological reactions mechanisms and their importance in diseases, focusing on the immature brain and kidneys. Furthermore, we study defense mechanisms that protect against these reactions with a special emphasis on the heme- and radical-scavenging protein A1M. Of particular interest is evaluating A1M as therapy for these conditions.Description
Redox reactions and oxidative stress has been implicated as an important factor in the progression of many disease conditions, such as hemorrhage, inflammation, infection, ischemia-reperfusion and tumor targeted radiation. During these conditions increased levels of free radicals are generated, causing an imbalance in the redox-system that leads to oxidation of cells and molecules and subsequent tissue and organ damage.UKÄ subject classification
- Infectious Medicine
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Magnus Gram
- Neonatology - Research project participant
- Redox Medicine
- Paediatrics (Lund) - Supervisor, Associate professor, Principal investigator
Person
Research output
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Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3
Ortenlöf, N., Vallius, S., Karlsson, H., Ekström, C., Kristiansson, A., Holmqvist, B., Göransson, O., Vaváková, M., Rydén, M., Carey, G., Barton, N., Ley, D. & Gram, M., 2023 Dec, In: Fluids and Barriers of the CNS. 20, 1, 59.Research output: Contribution to journal › Article › peer-review
Open Access -
Recombinant α 1-Microglobulin (rA1M) Protects against Hematopoietic and Renal Toxicity, Alone and in Combination with Amino Acids, in a 177Lu-DOTATATE Mouse Radiation Model.
Alattar, A. G., Kristiansson, A., Karlsson, H., Vallius, S., Ahlstedt, J., Forssell-Aronsson, E., Åkerström, B., Strand, S-E., Flygare, J. & Gram, M., 2023 Jun 1, In: Biomolecules. 13, 6, p. 1-13 923.Research output: Contribution to journal › Article › peer-review
Open Access -
Signaling to the immature brain - Choroid plexus, insulin-like growth factor 1 and extracellular vesicles
Ortenlöf, N., 2023, Lund: Lund University, Faculty of Medicine. 89 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile
Projects
- 1 Finished
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Blood: good and evil - ASG, Pufendorf IAS
Malm, T., Åkerström, B., Persson, F., Berner, B., Apelmo, E., Bengtsson, B. O., Bülow, L., Gram, M., Grantén, E., Hedling, E., Hill, A., Sellerberg, A. M., Storry, J., Svensson, J. & Svensson Chowdhury, M.
2015/08/15 → 2016/08/15
Project: Network
Prizes and distinction
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Finalist (honorary prize): Lund University and Sparbanksstiftelsen Finn's prize for future innovations
Smeds, Emanuel (Recipient), Gram, Magnus (Recipient) & Ortenlöf, Niklas (Recipient), 2017 Mar 15
Prize: Prize (including medals and awards)