Research output per year
Research output per year
Unit profile
Research
Our research uses advanced technology to generate neurons from novel cell sources with the aim to extensively define the subtype and function of the generated neurons and their potential for therapeutic use in the future. For this we are using reprogramming technology in animal models or human stem cell culture system, together with electrophysiology, RNA sequencing, tracing technologies and cell specific manipulation. In our most recent study we showed that it is possible to direct reprogram residual immune cells in the living brain into a specific type of interneurons that are implicated in several neurodegenerative diseases and psychiatric disorders. Our current aim is to continue this study with more extensive analysis of the new neurons and to assess their potential for future cell therapy for brain diseases.
Description
Our research uses advanced technology to generate neurons from novel cell sources with the aim to extensively define the subtype and function of the generated neurons and their potential for therapeutic use in the future. For this we are using reprogramming technology in animal models or human stem cell culture system, together with electrophysiology, RNA sequencing, tracing technologies and cell specific manipulation. In our most recent study we showed that it is possible to direct reprogram residual immune cells in the living brain into a specific type of interneurons that are implicated in several neurodegenerative diseases and psychiatric disorders. Our current aim is to continue this study with more extensive analysis of the new neurons and to assess their potential for future cell therapy for brain diseases.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Constanza Aretio
- Regenerative Neurophysiology - Doctoral student
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Doctoral student
- MultiPark: Multidisciplinary research focused on Parkinson´s disease - Doctoral student
Person
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Efrain Cepeda-Prado
- Regenerative Neurophysiology - Postdoc
- MultiPark: Multidisciplinary research focused on Parkinson´s disease - Postdoctoral fellow
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Postdoctoral fellow
Person
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Shayini Kidnapillai
- Regenerative Neurophysiology - Postdoctoral fellow
- MultiPark: Multidisciplinary research focused on Parkinson´s disease - Research engineer
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Postdoctoral fellow
Person
Research output
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3D model for human glia conversion into subtype-specific neurons, including dopamine neurons
Giacomoni, J., Bruzelius, A., Habekost, M., Kajtez, J., Ottosson, D. R., Fiorenzano, A., Storm, P. & Parmar, M., 2024 Sept, In: Cell reports methods. 4, 9, 100845.Research output: Contribution to journal › Article › peer-review
Open Access -
Label-FreeHigh-ResolutionPhotothermalOpticalInfraredSpectroscopyfor Spatiotemporal Chemica lAnalysis in Fresh, Hydrated Living Tissues and Embryos
Gvazava, N., Konings, S., Cepeda-Prado, E., Skoryk, V., Harrison Umeano, C., Dong, J., Augusto Silva, I., Rylander Ottosson , D., Leigh, N., Wagner, D. & Klementieva, O., 2023 Nov 2, In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
Open Access -
Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons
Martinez-Curiel, R., Jansson, L., Tsupykov, O., Avaliani, N., Aretio-Medina, C., Hidalgo, I., Monni, E., Bengzon, J., Skibo, G., Lindvall, O., Kokaia, Z. & Palma-Tortosa, S., 2023 Aug, In: Stem Cell Reports. 18, 8, p. 1643-1656 14 p.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 4 Active
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A 3D culture programming approach for modelling Interneuron pathologies in Schizophrenia
Ottosson, D. (PI)
2024/07/01 → 2026/06/30
Project: Research
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Reprogrammed Human Interneurons in an in vivo system
Aretio, C. (Researcher)
2023/05/15 → …
Project: Dissertation
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A self-healing brain for neurological disorders using in vivo reprogramming to interneurons
Ottosson, D. (PI)
2022/07/01 → 2027/06/30
Project: Research
Activities
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Neuroscience Day 2024
Björklund, A. (Member of programme committee), Ekdahl Clementson, C. (Member of programme committee), Garwicz, M. (Member of programme committee), Norrving, B. (Member of programme committee), Parmar, M. (Member of programme committee), Petersén, Å. (Member of programme committee), Hansson, O. (Member of programme committee), COMPAGNO STRANDBERG, M. (Member of programme committee), Ottosson, D. (Member of programme committee), Heuer, A. (Member of programme committee), Kokaia, M. (Member of programme committee), Mårtensson, J. (Member of programme committee), Castilla-Vallmanya, L. (Member of programme committee), Pettersson, P. (Organiser), Jakobsson, J. (Chair), Castilla-Vallmanya, L. (Organiser), Twohig, D. P. (Contributor), Cesaroni, V. (Contributor), Fernandez Calle, R. (Contributor), Arenas, E. (Invited speaker), Lignani, G. (Invited speaker), Beyeler, A. (Invited speaker), Adami, A. (Presenter), Bergh, S. (Presenter), Fritze, J. (Presenter), Hägg, A. (Presenter), Jukkola, J. (Presenter), Sozzi, E. (Presenter), Tampé, J. (Presenter), Schaefer, A. (Keynote/plenary speaker), Habekost, M. (Chair) & Wickham, J. (Chair)
2024 May 7Activity: Participating in or organising an event › Organisation of conference
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UniStem Day 2024: Dissemination and outreach of stem cell science
Ottosson, D. (Organiser), Magnusson, M. (Organiser), Kidnapillai, S. (Organiser), Ahlenius, H. (Organiser), Luis, A. B. (Organiser), Martinez Curiel, R. (Organiser), Laurin, K. (Organiser), Martos Salvo, P. (Organiser), Das, M. (Contributor), Wendler, M. (Contributor), Sivani, B. M. (Contributor), Ramos Passarello, G. (Contributor), Sozzi, E. (Contributor), García Garrote, M. (Contributor), Harrison Umeano, C. (Contributor), Okeke, U. C. (Contributor), Horvath, V. (Contributor), Garza, R. (Contributor), Adami, A. (Contributor), Castilla-Vallmanya, L. (Contributor), Gerdes, P. (Contributor), Pandiloski, N. (Contributor), Jin, Q. (Contributor), de Guidi, C. (Contributor), Palma Tortosa, S. (Contributor), Fritze, J. (Contributor), Jansson, L. I. (Contributor), Robles Rodriguez, L. (Contributor), Pracucci, E. (Contributor), Shen, Y.-P. (Contributor), Trovato, F. (Contributor), Tampé, J. (Contributor), Thakore, R. (Contributor), Stamouli, C.-A. (Contributor), Pinto dos Santos Vaz, C. (Contributor), Aretio, C. (Contributor), Piochon, C. (Contributor), Cepeda-Prado, E. (Contributor), de Jongh, M.-M. (Contributor), Tsalkitzidou, M. (Contributor), Bonsberger, J. (Contributor), Douse, C. (Contributor), Dorazehi, F. (Contributor), Koutounidou, S. (Contributor), Jarl, U. (Contributor), Corsi, S. (Contributor), Bruzelius, A. (Contributor), Mattsson, B. (Contributor), Hammarberg, A. (Contributor), Habekost, M. (Contributor), Prabhala, P. (Contributor), Bremborg, T. (Contributor), Nair, M. S. (Contributor), Burdeyron, P. (Contributor), Mazariegos, M. (Contributor), Björklund, M. (Contributor), Hidalgo, I. (Contributor), Hägg, A. (Invited speaker), Hammarlund, E. (Invited speaker), Mohlin, S. (Invited speaker) & Oesterle, M. (Contributor)
2024 Mar 22Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Neurobiology Section Retreat: 2024
Swanberg, M. (Organiser), Bonsberger, J. (Organiser), Hammarberg, A. (Organiser), Evilevitch, A. (Organiser) & Twohig, D. P. (Organiser)
2024 Mar 19Activity: Participating in or organising an event › Organisation of conference
Prizes and distinction
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Pristagare av Per-Eric och Ulla Schyberg stiftelse
Ottosson, D. (Recipient), 2020 Apr 28
Prize: Other distinction
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Harald and Greata Jeansson Award
Ottosson, D. (Recipient), 2019 May 21
Prize: Prize (including medals and awards)