SEBRA Sepsis and Bacterial Resistance Alliance

2025

Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial: a post hoc analysis

Bohm, M., Årestedt, K., Ullén, S., Nielsen, N., Dankiewicz, J., Friberg, H., Nordström, E. B., Cariou, A., Jakobsen, J. C., Grejs, A. M., Haenggi, M., Hammond, N. E., Heimburg, K., Keeble, T. R., Leithner, C., Rylander, C., Undén, J., Wise, M. P., Cronberg, T. & Lilja, G., 2025 Jul, In: Resuscitation Plus . 24, 100994.

Research output: Contribution to journal › Article › peer-review

Open Access

V-CARE (Virtual Care After REsuscitation): Protocol for a Randomized Feasibility Study of a Virtual Psychoeducational Intervention After Cardiac Arrest—A STEPCARE Sub-Study

Mion, M., Lilja, G., Bohm, M., Blennow Nordström, E., Töniste, D., Heimburg, K., Swindell, P., Dankiewicz, J., Skrifvars, M. B., Nielsen, N., Jakobsen, J. C., White, J., Wise, M. P., Gorgoraptis, N., Keenan, M., Hopkins, P., Pareek, N., Maccaroni, M. & Keeble, T. R., 2025 Jun 22, In: Journal of Clinical Medicine. 14, 13, 4429.

Research output: Contribution to journal › Article › peer-review

Open Access

Antibody-guided identification of Achromobacter xylosoxidans protein antigens in cystic fibrosis.

Sahl, C., Chowdhury, S., Malmström, J. & Påhlman, L. I., 2025 May, In: mSphere. p. 1-14 e0023325.

Research output: Contribution to journal › Article › peer-review

Open Access

Human proteome distribution atlas for tissue-specific plasma proteome dynamics

Malmström, E., Malmström, L., Hauri, S., Mohanty, T., Scott, A., Karlsson, C., Gueto-Tettay, C., Åhrman, E., Nozohoor, S., Tingstedt, B., Regner, S., Elfving, P., Bjermer, L., Forsvall, A., Doyle, A., Magnusson, M., Hedenfalk, I., Kannisto, P., Brandt, C. & Nilsson, E. & 5 others, Dahlin, L. B., Malm, J., Linder, A., Niméus, E. & Malmström, J., 2025 Apr 4, (E-pub ahead of print) In: Cell. p. 1-13

Research output: Contribution to journal › Article › peer-review

Open Access

Status of Sepsis Care in European Hospitals Results from an International Cross-Sectional Survey

Scheer, C. S., Giamarellos-Bourboulis, E. J., Ferrer, R., Idelevich, E. A., Annane, D., Artigas, A., Aslan, A. T., Bottari, G., Bouma, H. R., Černý, V., Radivojević, R. C., Dakou, K., Dewitte, K., Elbahnasawy, M., Gründling, M., Gurjar, M., Hästbacka, J., Kyprianou, M., Laribi, S. & Lassen, A. & 25 others, Lebedinskii, K., Máca, J., Malbrain, M. L. N. G., Monti, G., Ostermann, M., Osthoff, M., Paiva, J. A., Sabbatucci, M., Śmiechowicz, J., Ştefan, M. G., Vollmer, M., Vuković, N., Zaragkoulias, K., Reinhart, K., Linder, A., Filipescu, D., Ekman, A. (Contributor), Ibrahim-Baker, B. (Contributor), Kumar, R. (Contributor), Ljungquist, O. (Contributor), Mellhammar, L. (Contributor), Spångfors, M. (Contributor), Sundqvist, M. (Contributor), Tverring, J. (Contributor) & European Sepsis Care Study Group, 2025 Apr, In: American Journal of Respiratory and Critical Care Medicine. 211, 4, p. 587-599 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The predictive value of postoperative soluble urokinase plasminogen activator receptor concentration for postoperative complications following valvular surgery

Erixon, C., Thelaus, L., Johannesson, E., Nilsson, J., Teurneau-Hermansson, K., Linder, A., Ragnarsson, S., Sterner, N., Zindovic, I. & Dardashti, A., 2025 Mar 15, (E-pub ahead of print) In: Scandinavian Journal of Clinical and Laboratory Investigation.

Research output: Contribution to journal › Article › peer-review

Comparison of Self-Reported Physical Activity between Survivors of Out-of-Hospital Cardiac Arrest and Patients with Myocardial Infarction without cardiac arrest: a case-control study

Heimburg, K., Blennow Nordström, E., Friberg, H., Oestergaard, L. G., Grejs, A. M., Keeble, T. R., Kirkegaard, H., Mion, M., Nielsen, N., Rylander, C., Segerström, M., Tornberg, Å. B., Ullén, S., Undén, J., Wise, M. P., Cronberg, T. & Lilja, G., 2025 Feb 25, (E-pub ahead of print) In: European Journal of Cardiovascular Nursing.

Research output: Contribution to journal › Article › peer-review

Open Access

Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow

Gomez Toledo, A., Chowdhury, S., Hjortswang, E., Sorrentino, J. T., Lewis, N. E., Bläckberg, A., Ekström, S., Kjellström, S., Izadi, A., Olofsson, B., Nordenfelt, P., Malmström, L., Rasmussen, M. & Malmström, J., 2025 Feb 24, In: Nature Communications. 16, p. 1-16 1942.

Research output: Contribution to journal › Article › peer-review

Open Access

Epitope Mapping with Sidewinder: An XL-MS and Structural Modeling Approach

Ströbaek, J., Tang, D., Gueto-Tettay, C., Gomez Toledo, A., Olofsson, B., Hartman, E., Heusel, M., Malmström, J. & Malmström, L., 2025 Feb 11, In: International Journal of Molecular Sciences. 26, 4, p. 1-17 1488.

Research output: Contribution to journal › Article › peer-review

Open Access

Electrographic and Clinical Determinants of Good Outcome After Postanoxic Status Epilepticus

Admiraal, M. M., Backman, S., Annborn, M., Borgquist, O., Dankiewicz, J., Düring, J., Legriel, S., Lilja, G., Lindehammer, H., Nielsen, N., Rossetti, A. O., Undén, J., Cronberg, T., Westhall, E. & Ttm2 Trial Investigators, 2025 Feb, In: Neurology. 104, 5, e210304.

Research output: Contribution to journal › Article › peer-review

Open Access

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

Hefzi, H., Martínez-Monge, I., Marin de Mas, I., Cowie, N. L., Toledo, A. G., Noh, S. M., Karottki, K. J. L. C., Decker, M., Arnsdorf, J., Camacho-Zaragoza, J. M., Kol, S., Schoffelen, S., Pristovšek, N., Hansen, A. H., Miguez, A. A., Bjørn, S. P., Brøndum, K. K., Javidi, E. M., Jensen, K. L. & Stangl, L. & 15 others, Kreidl, E., Kallehauge, T. B., Ley, D., Ménard, P., Petersen, H. M., Sukhova, Z., Bauer, A., Casanova, E., Barron, N., Malmström, J., Nielsen, L. K., Lee, G. M., Kildegaard, H. F., Voldborg, B. G. & Lewis, N. E., 2025 Jan 14, (E-pub ahead of print) In: Nature Metabolism.

Research output: Contribution to journal › Article › peer-review

A prospective observational study on persistent postoperative pediatric pain, 4P: The study protocol

Broman, J., Nielsen, N. & Persson, A. K. M., 2025 Jan, In: PLoS ONE. 20, p. 1-10 e0316533.

Research output: Contribution to journal › Article › peer-review

Open Access

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

Johansson, J. M., Du Rietz, H., Hedlund, H., Eriksson, H. C., Oude Blenke, E., Pote, A., Harun, S., Nordenfelt, P., Lindfors, L. & Wittrup, A., 2025, In: Nature Communications. 16, 1, 5354.

Research output: Contribution to journal › Article › peer-review

Open Access

Comprehensive biobanking strategy with clinical impact at the European Cancer Moonshot Lund Center

Oskolas, H., Nogueira, F. C. N., Domont, G. B., Yu, K.-H., Semenov, Y. R., Sorger, P., Steinfelder, E., Corps, L., Schulz, L., Wieslander, E., Fenyö, D., Kárpáti, S., Holló, P., Kemény, L. V., Döme, B., Megyesfalvi, Z., Pawłowski, K., Nishimura, T., Kwon, H. & Encarnación-Guevara, S. & 16 others, Szasz, A. M., Veréb, Z., Gyulai, R., Németh, I. B., Appelqvist, R., Rezeli, M., Baldetorp, B., Horvatovich, P., Malmström, J., Pla, I., Sanchez, A., Knudsen, B., Kiss, A., Malm, J., Marko-Varga, G. & Gil, J., 2025, In: Journal of Proteomics. 316, 105442.

Research output: Contribution to journal › Review article › peer-review

Open Access

Deciphering protective immunity by multimodal mass spectrometry: Towards epitope-focused streptococcal vaccines

Tang, D., 2025, Lund: Lund University, Faculty of Medicine. 93 p.

Research output: Thesis › Doctoral Thesis (compilation)

Open Access

File

232 Downloads (Pure)

Fc-Engineered Antibodies Against SARS-CoV-2 and Streptococcus pyogenes: Therapeutic Potential via Enhanced Opsonization

Izadi, A., 2025, Lund: Lund University, Faculty of Medicine. 161 p.

Research output: Thesis › Doctoral Thesis (compilation)

Open Access

File

79 Downloads (Pure)

Unravelling the force-induced dynamics of integrin-based adhesion complexes

Sturgess, W., 2025, Lund: Lund University, Faculty of Medicine. 71 p.

Research output: Thesis › Doctoral Thesis (compilation)

Open Access

File

73 Downloads (Pure)

2024

Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis

McGuigan, P. J., Pauley, E., Eastwood, G., Hays, L. M. C., Jakobsen, J. C., Moseby-Knappe, M., Nichol, A. D., Nielsen, N., Skrifvars, M. B., Blackwood, B. & McAuley, D. F., 2024 Dec, In: Resuscitation. 205, 110431.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest

Arctaedius, I., Levin, H., Thorgeirsdóttir, B., Moseby-Knappe, M., Cronberg, T., Annborn, M., Nielsen, N., Zetterberg, H., Blennow, K., Ashton, N. J., Frigyesi, A., Friberg, H., Lybeck, A. & Mattsson-Carlgren, N., 2024 Dec, In: Critical Care. 28, 1, 116.

Research output: Contribution to journal › Article › peer-review

Open Access

Streptolysin O accelerates the conversion of plasminogen to plasmin

Tang, D., Khakzad, H., Hjortswang, E., Malmström, L., Ekström, S., Happonen, L. & Malmström, J., 2024 Nov 25, In: Nature Communications. 15, p. 1-15 15 p., 10212.

Research output: Contribution to journal › Article › peer-review

Open Access

Acoustic Trapping of Extracellular Vesicles

Broman, A., 2024 Nov 5, Lund: Lund University. 179 p.

Research output: Thesis › Doctoral Thesis (compilation)

File

64 Downloads (Pure)

CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathways

Johansson, K., Maouia, A., Rebetz, J., Marcoux, G., Shannon, O., Italiano, J. E., Narayanan, P., Henry, S., Shen, L. & Semple, J. W., 2024 Nov, In: Journal of Thrombosis and Haemostasis. 22, 11, p. 3266-3276 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted

Governa, V., de Oliveira, K. G., Bång-Rudenstam, A., Offer, S., Cerezo-Magaña, M., Li, J., Beyer, S., Johansson, M. C., Månsson, A. S., Edvardsson, C., Durmo, F., Gustafsson, E., Boukredine, A., Jeannot, P., Schmidt, K., Gezelius, E., Menard, J. A., Garza, R., Jakobsson, J. & de Neergaard, T. & 11 others, Sundgren, P. C., Tiihonen, A. M., Haapasalo, H., Rautajoki, K. J., Nordenfelt, P., Darabi, A., Forsberg-Nilsson, K., Pietras, A., Talbot, H., Bengzon, J. & Belting, M., 2024 Oct 30, In: Science Translational Medicine. 16, 771, p. eadk1168

Research output: Contribution to journal › Article › peer-review

Whole-channel acoustic energy and acoustophoretic efficiency frequency spectrum by the in-flow focusing method

Baasch, T., Qiu, W. & Laurell, T., 2024 Oct 18, In: Physical Review Applied. 22, 4, 12 p., 044049.

Research output: Contribution to journal › Article › peer-review

Open Access

Efficient Absorbance-Based Assay for Rapid Antibiotic Susceptibility Testing of Enterobacterales

Axelsson, C., Nilson, B. & Rehnstam-Holm, A.-S., 2024 Sept 6, In: Antibiotics. 13, 9, p. 1-9 852.

Research output: Contribution to journal › Article › peer-review

Open Access

EEG for good outcome prediction after cardiac arrest: A multicentre cohort study

Turella, S., Dankiewicz, J., Ben-Hamouda, N., Nilsen, K. B., Düring, J., Endisch, C., Engstrøm, M., Flügel, D., Gaspard, N., Grejs, A. M., Haenggi, M., Haffey, S., Imbach, L., Johnsen, B., Kemlink, D., Leithner, C., Legriel, S., Lindehammar, H., Mazzon, G. & Nielsen, N. & 11 others, Peyre, A., Ribalta Stanford, B., Roman-Pognuz, E., Rossetti, A. O., Schrag, C., Valeriánová, A., Wendel-Garcia, P., Zubler, F., Cronberg, T., Westhall, E. & the TTM2 trial investigators, 2024 Sept, In: Resuscitation. 202, 110319.

Research output: Contribution to journal › Article › peer-review

Open Access

Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data

Hartman, E., Forsberg, F., Kjellström, S., Petrlova, J., Luo, C., Scott, A., Puthia, M., Malmström, J. & Schmidtchen, A., 2024 Aug 20, In: Nature Communications. 15, 1, 7128.

Research output: Contribution to journal › Article › peer-review

Open Access

Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells

Hefzi, H., Martínez-Monge, I., Marin de Mas, I., Cowie, N. L., Toledo, A. G., Noh, S. M., Karottki, K. J. L. C., Decker, M., Arnsdorf, J., Camacho-Zaragoza, J. M., Kol, S., Schoffelen, S., Pristovšek, N., Hansen, A. H., Miguez, A. A., Bjorn, S. P., Brøndum, K. K., Javidi, E. M., Jensen, K. L. & Stangl, L. & 15 others, Kreidl, E., Kallehauge, T. B., Ley, D., Ménard, P., Petersen, H. M., Sukhova, Z., Bauer, A., Casanova, E., Barron, N., Malmström, J., Nielsen, L. K., Lee, G. M., Kildegaard, H. F., Voldborg, B. G. & Lewis, N. E., 2024 Aug 6, bioRxiv, (bioRxiv : the preprint server for biology).

Research output: Working paper/Preprint › Preprint (in preprint archive)

Open Access

Protective non-neutralizing SARS-CoV-2 monoclonal antibodies

Izadi, A. & Nordenfelt, P., 2024 Aug, In: Trends in Immunology. 45, 8, p. 609-624

Research output: Contribution to journal › Review article › peer-review

Open Access

Protective Non-neutralizing anti-N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence

Izadi, A., Godzwon, M., Söderlund Strand, A., Schmidt, T., Kumlien Georén, S., Drosten, C., Ohlin, M. & Nordenfelt, P., 2024 Jul 17, In: Journal of immunology. 213, 5, p. 678-689

Research output: Contribution to journal › Article › peer-review

Open Access

Long-term Mortality and Hospital Readmissions Among Survivors of Sepsis in Sweden: A Population-Based Cohort Study

Inghammar, M., Linder, A., Lengquist, M., Frigyesi, A., Wetterberg, H., Sundén-Cullberg, J. & Nilsson, A., 2024 Jul, In: Open Forum Infectious Diseases. 11, 7, ofae331.

Research output: Contribution to journal › Article › peer-review

Open Access

Regional Brain Net Water Uptake in Computed Tomography after Cardiac Arrest – A Novel Biomarker for Neuroprognostication

Kenda, M., Lang, M., Nee, J., Hinrichs, C., Dell'Orco, A., Salih, F., Kemmling, A., Nielsen, N., Wise, M., Thomas, M., Düring, J., McGuigan, P., Cronberg, T., Scheel, M., Moseby-Knappe, M. & Leithner, C., 2024 Jul, In: Resuscitation. 200, 110243.

Research output: Contribution to journal › Article › peer-review

Open Access

Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest: a prospective multicentre study

Lang, M., Kenda, M., Scheel, M., Martola, J., Wheeler, M., Owen, S., Johnsson, M., Annborn, M., Dankiewicz, J., Deye, N., Düring, J., Friberg, H., Halliday, T., Jakobsen, J. C., Lascarrou, J. B., Levin, H., Lilja, G., Lybeck, A., McGuigan, P. & Rylander, C. & 10 others, Sem, V., Thomas, M., Ullén, S., Undén, J., Wise, M. P., Cronberg, T., Wassélius, J., Nielsen, N., Leithner, C. & Moseby-Knappe, M., 2024 Jul, In: Intensive Care Medicine. 50, 7, p. 1096-1107 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

Tang, D., Gueto-Tettay, C., Hjortswang, E., Ströbaek, J., Ekström, S., Happonen, L., Malmström, L. & Malmström, J., 2024 Jun 4, In: Analytical Chemistry. 96, 22, p. 9060–9068

Research output: Contribution to journal › Article › peer-review

Open Access

Cannabis use, mental health, and problematic Internet use in Quebec: A study protocol

Brodeur, M., Jutras-Aswad, D., Légaré, A. A., Morvannou, A., Monson, E., Cotton, J. C., Hakansson, A., Parent, V. & Hudon, C., 2024 Jun, In: PLoS ONE. 19, 6 June, e0304697.

Research output: Contribution to journal › Article › peer-review

Open Access

Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial

Lindén, A., Spångfors, M., Olsen, M. H., Fisher, J., Lilja, G., Sjövall, F., Jungner, M., Lengquist, M., Kander, T., Samuelsson, L., Johansson, J., Palmnäs, E., Undén, J., Oras, J., Cronhjort, M., Chew, M., Linder, A., Lipcsey, M., Nielsen, N. & Jakobsen, J. C. & 2 others, Bentzer, P. & REDUSE Trial Group, 2024 May 17, In: Critical care (London, England). 28, 1, 166.

Research output: Contribution to journal › Article › peer-review

Open Access

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies

Izadi, A., Karami, Y., Bratanis, E., Wrighton, S., Khakzad, H., Nyblom, M., Olofsson, B., Happonen, L., Tang, D., Sundwall, M., Godzwon, M., Chao, Y., Gomez Toledo, A., Schmidt, T., Ohlin, M., Nilges, M., Malmström, J., Bahnan, W., Shannon, O. & Malmström, L. & 1 others, Nordenfelt, P., 2024 Apr 15, In: Nature Communications. 15, p. 1-22 3600.

Research output: Contribution to journal › Article › peer-review

Open Access

EVALUATION OF A NEUROCOGNITIVE SCREENING FOR OUT-OF-HOSPITAL CARDIAC ARREST SURVIVORS

Blennow Nordström, E., Evald, L., Mion, M., Segerström, M., Vestberg, S., Ullén, S., Friberg, H., Heimburg, K., Gregersen Oestergaard, L., Grejs, A. M., Keeble, T., Kirkegaard, H., Rylander, C., Wise, M., Nielsen, N., Cronberg, T. & Lilja, G., 2024 Apr 2, In: Journal of the American College of Cardiology. 83, 13, Supplement, p. 1198

Research output: Contribution to journal › Published meeting abstract › peer-review

Eubacterium bacteremia – a retrospective observational study of a seldom found anaerobic pathogen

Bläckberg, A., Holm, K., Liderot, K., Nilson, B. & Sunnerhagen, T., 2024 Apr, In: Diagnostic Microbiology and Infectious Disease. 108, 4, 116185.

Research output: Contribution to journal › Article › peer-review

Open Access

File

276 Downloads (Pure)

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

De Marchi, T., Lai, C.-F., Simmons, G. M., Goldsbrough, I., Harrod, A., Lam, T., Buluwela, L., Kjellström, S., Brueffer, C., Saal, L. H., Malmström, J., Ali, S. & Niméus, E., 2024 Mar 22, In: Scientific Reports. 14, p. 1-16 6873.

Research output: Contribution to journal › Article › peer-review

Open Access

Silica seed particles improve the efficiency and throughput of nanoparticle acoustic trapping

Havers, M., Baasch, T., Lenshof, A., Evander, M. & Laurell, T., 2024 Mar, In: Physical Review Applied. 21, 3, 034016.

Research output: Contribution to journal › Article › peer-review

Open Access

Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche

de Oliveira, K. G., Bång-Rudenstam, A., Beyer, S., Boukredine, A., Talbot, H., Governa, V., Johansson, M. C., Månsson, A.-S., Forsberg-Nilsson, K., Bengzon, J., Malmström, J., Welinder, C. & Belting, M., 2024 Feb 27, In: Acta Neuropathologica Communications. 12, 1, 35.

Research output: Contribution to journal › Article › peer-review

Open Access

Population scale proteomics enables adaptive digital twin modelling in sepsis

Scott, A. M., Mellhammar, L., Malmström, E., Gustafsson, A. G., Bakochi, A., Isaksson, M., Mohanty, T., Thelaus, L., Kahn, F., Malmström, L., Malmström, J. & Linder, A., 2024 Jan 1, medRxiv.

Research output: Working paper/Preprint › Preprint (in preprint archive)

The first report of Staphylococcus argenteus endocarditis with visualized valve vegetations

Hillstedt, E., Dencker, M., Nilson, B., Oldberg, K. & Rasmussen, M., 2024 Jan, In: IDCases. 37, e02058.

Research output: Contribution to journal › Article › peer-review

Open Access

Acoustic Enrichment of Heterogeneous Circulating Tumor Cells and Clusters from Metastatic Prostate Cancer Patients

Magnusson, C., Augustsson, P., Undvall Anand, E., Lenshof, A., Josefsson, A., Welén, K., Bjartell, A., Ceder, Y., Lilja, H. & Laurell, T., 2024, In: Analytical Chemistry. 96, 18, p. 6914-6921

Research output: Contribution to journal › Article › peer-review

Open Access

An Equine Protein Atlas Highlights Synovial Fluid Proteome Dynamics during Experimentally LPS-Induced Arthritis

Bundgaard, L., Årman, F., Åhrman, E., Walters, M., Auf dem Keller, U., Malmström, J. & Jacobsen, S., 2024, In: Journal of Proteome Research. 23, 11, p. 4849-4863

Research output: Contribution to journal › Article › peer-review

Open Access