Research output per year
Research output per year
Unit profile
Research
Many cancer patients are treated with chemotherapy that unspecifically targets all proliferative cells leading to severe side effects and a high relapse rate. The high relapse rate is a result of the inefficiency of conventional therapy to eradicate the cancer stem cells (CSC) that are believed to drive the disease and to be resistant to chemotherapy. Our goal is to understand the mechanisms driving cancer by functionally and molecularly identifying the cancer stem cells that are resistant to chemotherapy. In addition, we aim to develop a small molecule platform for drug profiling in order to find the most optimal drug combination for each patient targeting all cancer cells including the cancer stem cells. Our hope is that our results will improve survival and patient suffering during treatment, which will also have a positive effect on the socio-economic level.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Mattias Magnusson
- Division of Molecular Medicine and Gene Therapy - Associate professor
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Principal investigator
- Stem cell and Cancer stem cell Regulation - Research team manager
- LUCC: Lund University Cancer Centre - Principal investigator
Person
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Pavan Prabhala
- Stem cell and Cancer stem cell Regulation - Postdoctoral fellow
- Division of Molecular Medicine and Gene Therapy - Postdoctoral fellow
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Postdoctoral fellow
- LUCC: Lund University Cancer Centre - Researcher
Person
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Jiten Sharma
- Stem cell and Cancer stem cell Regulation - Postdoctoral fellow
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Postdoctoral fellow
Person
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3D cultivation of non-small-cell lung cancer cell lines using four different methods
Malmros, K., Kirova, N., Kotarsky, H., Carlsén, D., Mansour, M. S. I., Magnusson, M., Prabhala, P. & Brunnström, H., 2024 Oct 23, In: Journal of Cancer Research and Clinical Oncology. 150, p. 1-10 472.Research output: Contribution to journal › Article › peer-review
Open Access -
MYCT1 controls environmental sensing in human haematopoietic stem cells
Aguadé-Gorgorió, J., Jami-Alahmadi, Y., Calvanese, V., Kardouh, M., Fares, I., Johnson, H., Rezek, V., Ma, F., Magnusson, M., Wang, Y., Shin, J. E., Nance, K. J., Goodridge, H. S., Liebscher, S., Schenke-Layland, K., Crooks, G. M., Wohlschlegel, J. A. & Mikkola, H. K. A., 2024 Jun 13, In: Nature. 630, 8016, p. 412-420 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Role of the co-transcriptional regulators Yap/Taz in the normal and fibrotic lung epithelia
Alsafadi, H. N., 2023, Lund: Lund University, Faculty of Medicine. 81 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile
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Preventing development and progression of lung cancer
Magnusson, M. (PI)
2024/01/01 → 2027/12/31
Project: Research
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Characterising the landscape of human lung epithelial stem/progenitor cells
Wijk, S. (Research student) & Magnusson, M. (PI)
2016/06/01 → …
Project: Dissertation
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Målinriktad terapi för att övervinna läkemedelsresistens hos barn med akut myeloisk leukemi
Magnusson, M. (PI)
The Swedish Childhood Cancer Fund
2023/01/01 → 2024/12/31
Project: Research
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UniStem Day 2024: Dissemination and outreach of stem cell science
Ottosson, D. (Organiser), Magnusson, M. (Organiser), Kidnapillai, S. (Organiser), Ahlenius, H. (Organiser), Luis, A. B. (Organiser), Martinez Curiel, R. (Organiser), Laurin, K. (Organiser), Martos Salvo, P. (Organiser), Das, M. (Contributor), Wendler, M. (Contributor), Sivani, B. M. (Contributor), Ramos Passarello, G. (Contributor), Sozzi, E. (Contributor), García Garrote, M. (Contributor), Harrison Umeano, C. (Contributor), Okeke, U. C. (Contributor), Horvath, V. (Contributor), Garza, R. (Contributor), Adami, A. (Contributor), Castilla-Vallmanya, L. (Contributor), Gerdes, P. (Contributor), Pandiloski, N. (Contributor), Jin, Q. (Contributor), de Guidi, C. (Contributor), Palma Tortosa, S. (Contributor), Fritze, J. (Contributor), Jansson, L. I. (Contributor), Robles Rodriguez, L. (Contributor), Pracucci, E. (Contributor), Shen, Y.-P. (Contributor), Trovato, F. (Contributor), Tampé, J. (Contributor), Thakore, R. (Contributor), Stamouli, C.-A. (Contributor), Pinto dos Santos Vaz, C. (Contributor), Aretio, C. (Contributor), Piochon, C. (Contributor), Cepeda-Prado, E. (Contributor), de Jongh, M.-M. (Contributor), Tsalkitzidou, M. (Contributor), Bonsberger, J. (Contributor), Douse, C. (Contributor), Dorazehi, F. (Contributor), Koutounidou, S. (Contributor), Jarl, U. (Contributor), Corsi, S. (Contributor), Bruzelius, A. (Contributor), Mattsson, B. (Contributor), Hammarberg, A. (Contributor), Habekost, M. (Contributor), Prabhala, P. (Contributor), Bremborg, T. (Contributor), Nair, M. S. (Contributor), Burdeyron, P. (Contributor), Mazariegos, M. (Contributor), Björklund, M. (Contributor), Hidalgo, I. (Contributor), Hägg, A. (Invited speaker), Hammarlund, E. (Invited speaker), Mohlin, S. (Invited speaker) & Oesterle, M. (Contributor)
2024 Mar 22Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Unistem Day 2020
Karlsson, G. (Organiser), Karlsson, C. (Organiser), Pettersson, P. (Organiser), McKay, C. (Organiser), Ahlenius, H. (Organiser), Parmar, M. (Organiser), Magnusson, M. (Organiser), Warfvinge, R. (Organiser), Nolbrant, S. (Speaker), Johansson, P. (Contributor), Atacho, D. (Contributor), Shrigley, S. (Contributor), Jarl, U. (Contributor), Sparrenius, M. (Contributor), Mattsson, B. (Contributor), Hoban, D. (Contributor), Fiorenzano, A. (Contributor), Giacomoni, J. (Contributor), Nilsson, F. (Contributor), Sozzi, E. (Contributor), Hammarberg, A. (Contributor), Pircs, K. (Contributor), Bruzelius, A. (Contributor), Birtele, M. (Contributor), Kidnapillai, S. (Contributor), Cepeda-Prado, E. (Contributor), Mikulik, K. (Contributor), Garza, R. (Contributor) & Storm, P. (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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