Research output per year
Research output per year
Unit profile
Research
Hematopoiesis is a well-balanced system that requires both consistency and flexibility. Although the potential of hematopoietic stem cells (HSCs) has intensively been studied, contributions of these cells in different occasions and their regulations are still unclear. Our research group therefore aims to understand molecular mechanisms and cellular dynamics of HSCs, particularly under proliferative and stressed conditions. Concretely, we study (1) how different kinds of stress impact on cellular metabolism and stem cell heterogeneity, (2) how cells manage such stress conditions, and (3) what types of factors can play the role in the regulations. These are crucial for investigating molecular/cellular mechanisms involved in normal and malignant hematopoiesis, and also equally imperative for developing new technologies in order to expand/produce functional blood cells.Description
UKÄ subject classification
- Cell and Molecular Biology
Free keywords
- Hematopoiesis
- unfolded protein stress
- red blood cell
- bile acid
- erythropoiesis
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Kenichi Miharada
- Division of Molecular Medicine and Gene Therapy - Researcher
- Stem Cell Metabolism - Research team manager
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Principal investigator
- LUCC: Lund University Cancer Centre - Principal investigator
Person
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Visnja Radulovic
- Division of Molecular Medicine and Gene Therapy - Postdoctoral fellow
- Stem Cell Metabolism - Postdoctoral fellow
- LUCC: Lund University Cancer Centre - Researcher
Person
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Kiyoka Saito
- Stem Cell Metabolism - Postdoctoral fellow
- Division of Molecular Medicine and Gene Therapy - Postdoctoral fellow
Person
Research output
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Restoring tumor immunogenicity with dendritic cell reprogramming
Zimmermannova, O., Ferreira, A. G., Ascic, E., Velasco Santiago, M., Kurochkin, I., Hansen, M., Met, Ö., Caiado, I., Shapiro, I. E., Michaux, J., Humbert, M., Soto-Cabrera, D., Benonisson, H., Silvério-Alves, R., Gomez-Jimenez, D., Bernardo, C., Bauden, M., Andersson, R., Höglund, M., Miharada, K., & 9 others, 2023 Jul 7, In: Science Immunology. 8, 85, eadd4817.Research output: Contribution to journal › Article › peer-review
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Blood in a Lab: Using Immortalized Erythroid Cell Lines as a Source for Blood Transfusion
Soboleva, S., 2022, Lund: Lund University, Faculty of Medicine. 88 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile -
CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture
Koide, S., Sigurdsson, V., Radulovic, V., Saito, K., Zheng, Z., Lang, S., Soneji, S., Iwama, A. & Miharada, K., 2022 Jan 21, In: iScience. 25, 1, 103603.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active
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Hematopoietic stem cell dynamics during regeneration
Rydström, A., Larsson, J., Bryder, D. & Miharada, K.
2019/04/01 → …
Project: Dissertation